Merck Report

Many of the papers from Merck reported the 1 1 complex of lithium acetylide and lithium alkoxide of the chiral modifier as monomer and the dimer of the 1 1 complex as tetramer. 

Merck reported the synthesis and isolation of (7 )-3,5-bistrifluoromethylphenylethanol (170) in high yields and enantiomeric excess by asymmetric hydrogen transfer. Reduction of 3,5-bistrifluoro-acetophenone (128, Ar = 3,5-(CF3)2C6H3, R = Me) with catalyst 169, prepared in situ from [RuCl2(p-cymene)]2 and (I S,2R)-cA-l-aminoindan-2-ol, produced the chiral alcohol 170 in 91-93% ee (Scheme 12.67).213... 

Schwartz and co-workers, also at Merck, reported the isolation and elucidation of the structure of pramanicin (12) and a related fatty acid that were discovered during a search for novel antifungal agents.60 The authors reported using a 500 MHz 3 mm micro-inverse probe for the acquisition of the heteronuclear 2D-NMR data to characterize the molecule, including a HMQC spectrum. 

Merck s Reagenzien-Verzeichnis (1903, 1907, 1913. 1916, 1924, 1928, 1932, 1936), in German. Useful reagents and reactions listed according to author s name. Afterwards appeared serially in translation in American Merck s Report and Merck Report and reproduced in Merck Index (5th edition). 

The Merck Report (1892-, issued quarterly). Merck s Market Report and Pharmaceutical Journal (Merck Co.), 89 -96 Vols. I to V). Merck s Report (Merck Co., 1897-1927 Merck Co., Inc., 1927-34). A practical journal of pharmacy, materia medica, and chemistry, with a section of each quarterly devoted to current price lists. The Merck Report (Merck Co., Inc., 1934-, Vol. 43-). For many yeare Theo. Holm contributed a series of articles on Medicinal Plants of North America with figures drawn from nature. This extensive series, covering 99 plants, has never been reproduced elsewhere and is often cited by botanists and pharmacognosists. 

IBM Journal of Research and Development Nickel Bulletin Platinum Metals Review Research Today Industrial Bulletin Science Tools Merck Report Seminar Report Instrumentation Oakite News Service Laundry Bundle Electronic Age By Gum... 

Merck s Index [1897, 1902, 1910, 1914 (in French), 1927, 1928 (in 1930 in Spanish), 1935 (in French) ]. A collective index of preparations, drugs, and minerals listed by E. Merck with descriptions of their chemical composition, physical properties, and medical, technical, and other uses. Merck s Reagenzien-Verzeichnis (1903, 1907, 1913, 1916, 1924, 1928, 1932, 1936), in German. Useful reagents and reactions listed according to author s name. Afterwards appeared serially in translation in American Merck s Report and Merck Report and reproduced in Merck Index (5th edition). 

Lederle Laboratories Division, American Cyanamid Co., New York, N. Y. Merck Report (R, N)... 

Merck reported that certain 19-substituted androstene diol derivatives exhibited a remarkable degree of ERP selectivity [103]. However, in many cases the compounds... 

The Merck Report a report by George W. Merck, the Director of the War Research Service (194 ). 

Now, Merck reported in the wake of results from a combination study, that it had withdrawn all its niacin containing drugs. 

Chemists at Merck reported an effective palladium-catalyzed arylation protocol for imidazo[l,2-fl]pyrimidme (164) (Scheme 10.57). Using a Pd(0Ac)2/PPh3/K2C03 catalytic manifold, the authors found that arylation with various aryl bromides occurred exclusively at the C3 position of the imidazole B-ring to afford products 165A-D in good to high yields. 

Merck report, October 1943 H. M. Crooks in The Chemistry of Penicillin , Princeton Univ. Press, 1943. 

Shortly after the discovery of cephamycin antibiotics, a group at Merck reported on the stereospecific introduction of a methoxy moiety into the 7(6)-position of both cephalosporin and penicillin nuclei. Cama and coworkers (1972) utilized benzhydryl 7-diazocephalosporanate (26) which... 

Biological Warfare, Report to the Secretary of War by Mr. George W. Merck, Special Consultant for Biological Warfare, The Military Surgeon, XCVIII (1946), 237-42. This is the so-called Merck Report, which appeared in various publications but with slight variations in the contents of certain paragraphs. 

In 2006, the group from Merck reported an interesting utilization of various commercially available ketoreductases (KREDs) for the reduction of a.p-unsaturated ketones 12 and 13 for the synthesis of chiral allylic alcohols 14 and IS [19]. This enzymatic reduction combined with a dynamic kinetic racemization proved to be a very powerful method for the production of optically pure product in excellent yield starting from a racemic ketone, as shown in Scheme 12.7. 

The final reaction sequence to prepare the aldehyde 4 is shown in Scheme 10. The second metal-halogen exchange to form 18, with an inverse addition of 13 to butyllithium in analogy to the Merck report, was followed by addition of DMF to trap the aryllithium. An inverse quench of this tetrahedral intermediate... 

Chung and co-workers [24] at Merck reported a multikilogram synthesis of naphthyridinone 55, a p38 MAP kinase inhibitor for the treatment of rheumatoid arthritis, Crohn s disease, and psoriasis. An improved biphasic Suzuki coupling of chloronaphthyridinone 52 and 2,4-difluorophenylboionic acid 53, catalyzed by Pd(OAc) gave drug precursor 54 in 91% yield (Scheme 9.14). 

Researchers at Merck reported SAD reaction of a styrene derivative 164 for the synthesis of the substance-P inhibitor 166 [80], SAD on 164 using AD-mix a gave crude diol 165 with 87% ee optical purity, which was further upgraded to > 99% ee upon recrystallization (Scheme 9.44). Noteworthy, of the process is that the stereochemistry created in dihydroxylation reaction is responsible for the origin in installation of all the three chiral centers in the final drug substance. 

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