Mercaptoacetic acid ethanol

The rapid synthesis of 4-thiazolidinones by the MCR of an amine, aldehyde and mercaptoacetic acid has been developed under microwave-assisted conditions [73-75]. Irradiation of the three components in ethanol at 120 °C in the presence of molecular sieves [73] or in toluene at reflux under atmospheric conditions [74] in a single-mode microwave synthesizer gave the... 

More recently, Miller and coworkers have reported a one-pot protocol for the preparation of thiazolidin-4-ones by condensation of aromatic aldehydes, amines, and mercaptoacetic acid in ethanol (Scheme 6.215 b) [387]. The optimized procedure involved microwave irradiation of a mixture of the amine hydrochloride, aldehyde,... 

Thiazolidones are another class of heterocycles that attract much attention because of their wide ranging biological activity [106], They are usually synthesized by three-component condensation of a primary amine, an aldehyde, and mercapto-acetic acid with removal, by azeotropic distillation, of the water formed [107]. The reaction is believed to proceed via imine formation then attack of sulfur on the imine carbon. Finally, an intramolecular cyclization with concomitant elimination of water occurs, generating the desired product. The general applicability of the reaction is limited, however, because it requires prolonged heating with continuous removal of water. To circumvent these difficulties and to speed up the synthesis, Miller et al. developed a microwave-accelerated three-component reaction for the synthesis of 4-thiazolidinones 63 [108]. In this one-pot procedure, a primary amine, an aldehyde, and mercaptoacetic acid were condensed in ethanol under MW conditions for 30 min at 120 °C (Scheme 17.44). The desired 4-thiazolidinones 63 were obtained in 55-91% yield. 

Mercaptoacetic acid 2,2-bis-mercaptoacetoxymethyl butyl ester. See Trimethylolpropane trithioglycolate Mercaptoacetic acid, calcium deriv.. See Calcium thioglycolate Mercaptoacetic acid, compd. with 2-aminoethanol (1 1). See Ethanol amine thioglycolate... 

A method has been described for attaching semiconductor GdS nanocrystals to metal (Au and Al) surfaces using difunctional SAMs as bridge compounds [42]. SAMs were prepared by immersing Au substrates in 5 mM ethanolic solutions of 1,3-propanedithiol, 1,6-hexanedithiol, and 1,8-octanedithiol for 8-12 hours. Al substrates were placed in solutions of 5 mM mercaptoacetic acid dissolved in ethanol and were allowed to sit for 12 hours. After immersion, the samples were removed... 

Gududuru et al. (2004) have reported a convenient microwave method for the synthesis of 4-thiazolidinones via the one pot condensation of a primary amine, an aldehyde, and mercaptoacetic acid. The reactions were conducted using an environmentally benign solvent ethanol in open vessels at atmospheric pressure in the... 

Hydroxythiophenes from a-mercapto-carboxylic acid esters. 4-Methylpenta-2,3-dienenitrile added dropwise with stirring during 5 min. to a suspension of methyl sodium sulfidoacetate (prepared from mercaptoacetate and Na-ethoxide in abs. ethanol) in anhydrous ether, and stirred 1 hr. at room temp, after the mildly exothermic reaction has ceased -> 4-hydroxy-2-isopropylthiophene-3-carbonitrile. 

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