Meningococcal vaccines

Meningococcal vaccine. (Minimum age 7 7 years for meningococcal conjugate vaccine [MCZ4] 2 years for meningococcal polysaccharide vaccine [MPSV4])... 

The strength may be expressed in terms of the total amount (p,g) of immunogen present in each milliliter or dose of vaccine (e.g., meningococcal vaccine). 

If the recommended dose for meningococcal vaccine is 1 injection of 0.5 mL at 0.1 mg/mL, how many immunizations can a 10-mL multi-use vial yield ... 

Meningococcal vaccines Purified surface polysaccharide antigens of one or more strains of Neisseria meningitidis Active immunization against Neisseria meningitidis (can cause meningitis and septicaemia)... 

Epidemics of bacterial meningitis have been described in crowded places such as military institutions and schools. In some countries in Africa ( meningococcal belt ) the incidence of seasonal meningococcal meningitis is so high that meningococcal vaccination is advised. 

In contrast to the pneumococcal vaccine, however, the composition of the meningococcal vaccine was greatly simplified, due to the fact that fewer polysaccharides were required. Based on their capsular polysaccharides, there are only eight different serogroups of N. meningitidis (A, B, C, 29e, W-135, X, Y, and Z), of which, groups A, B, and... 

Meningococcal vaccines have been comprehensively reviewed, distinguishing conventional polysaccharide vaccines, non-polysaccharide group B meningococcal vaccines, and conjugated meningococcal vaccines (1). 

From studies in 370 infants and children and 171 adults aged 18-30 years, who received three doses of outer membrane protein meningococcal vaccine developed in either Cuba or Norway or a control vaccine (Hib vaccine), the vaccines are promising candidates for the control of epidemics caused by homologous epidemic strains (5). However, the vaccines would not confer protection during a heterologous epidemic. All vaccinees had more pain, induration, and erythema at the injection site than did Hib vaccine recipients there were no serious adverse events, and 95% of individuals who reported symptoms said that the symptoms did not interfere with their normal activities. 

Data on adverse events reported to a passive provincial surveillance system have been evaluated after the mass immunization with a polysaccharide meningococcal vaccine of 1 198 751 people aged 6 months to 20 years in Quebec. A total of 118 reports of severe adverse events were selected. The most frequent were allergic reactions (9.2 per 100 000 doses), followed by few neurological reactions (0.5 per 100 000 doses) and very few anaphylactic reactions (0.1 per 100 000 doses). There were no reports of long-lasting sequelae or of encephalopathy, encephalitis, or meningitis (15). 

Peltola H. Meningococcal vaccines. Current status and future possibilities. Drugs 1998 55(3) 347-66. 

Peltola H, Safary A, Kayhty H, Karanko V, Andre FE. Evaluation of two tetravalent (ACYW135) meningococcal vaccines in infants and small children a clinical study comparing immunogenicity of O-acetyl-negative and O-acetyl-positive group C polysaccharides. Pediatrics 1985 76(l) 91-6. 

Hood DA, Edwards IR. Meningococcal vaccine—do some children experience side effects NZ Med J 1989 102(862) 65-7. 

Yergeau A, Alain L, Pless R, Robert Y. Adverse events temporally associated with meningococcal vaccines. CMAJ 1996 154(4) 503-7. 

Meningococcal vaccine is an inactivated vaccine composed of capsular polysaccharide fragments of Neisseria meningitidis. There are four polysaccharide serotypes represented in the vaccine A. C. Y, and W-135. The type A polysaccharide consists of a polymer of Af-acctyl-O-mannosaminc phosphate the group C polysaccharide is mostly Af-acctyl-O-ace-tylncuraminic acid. Indications are... 

Administration of routine immunizations as recommended by the American Academy of Pediatrics is crucial. In addition to the routine immunizations, SCD patients 6 months and older should also receive itrfluenza vaccine atmually. Meningococcal vaccine is also recommended for patients greater than 2 years of age undergoing splenectomy. ... 

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