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Membrane lipid bilayers detergent-resistant membranes

Although the majority of the lipids in M. laidlawii membranes appear to be in a liquid-crystalline state, the system possesses the same physical properties that many other membranes possess. The ORD is that of a red-shifted a-helix high resolution NMR does not show obvious absorption by hydrocarbon protons, and infrared spectroscopy shows no ft structure. Like erythrocyte ghosts, treatment with pronase leaves an enzyme-resistant core containing about 20% of the protein of the intact membrane (56). This residual core retains the membrane lipid and appears membranous in the electron microscope (56). Like many others, M. laidlawii membranes are solubilized by detergents and can be reconstituted by removal of detergent. Apparently all of these properties can be consistent with a structure in which the lipids are predominantly in the bilayer conformation. The spectroscopic data are therefore insufficient to reject the concept of a phospholipid bilayer structure or to... [Pg.304]

Although the Fluid Mosaic Model assumes a homogeneous distribution of lipid throughout the bilayer, lateral phase separation can be observed in model membranes composed of mixtures of lipids (Figure 2b). The first indication that similar effects occurred in vivo was the discovery of cholesterol-rich and detergent-resistant fractions of cell membranes, dubbed lipid rafts. These rafts, described... [Pg.3254]


See other pages where Membrane lipid bilayers detergent-resistant membranes is mentioned: [Pg.32]    [Pg.431]    [Pg.576]    [Pg.230]    [Pg.174]    [Pg.118]    [Pg.382]    [Pg.131]    [Pg.88]    [Pg.230]    [Pg.140]    [Pg.278]    [Pg.306]    [Pg.230]    [Pg.230]   
See also in sourсe #XX -- [ Pg.48 ]




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Bilayer resist

Bilayer, lipidic

Detergent resistance

Detergent resistant membrane

Detergents lipids

Lipid bilayer

Lipid bilayers

Membrane bilayer

Membrane lipid bilayers

Membranes bilayers

Resists bilayer

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