Membrane electroporation

The first model of membrane electroporation was suggested by Crowley [1]. In Crowley s model the membrane is viewed as the isotropic elastic material. The necessary background for understanding its voltage-induced instability was discussed in Section II. Crowley s approximation for the elasticity energy term in Eq. (7) is... 

As has been described in Ref. 70, this approach can reasonably account for membrane electroporation, reversible and irreversible. On the other hand, a theory of the processes leading to formation of the initial (hydrophobic) pores has not yet been developed. Existing approaches to the description of the probability of pore formation, in addition to the barrier parameters F, y, and some others (accounting, e.g., for the possible dependence of r on r), also involve parameters such as the diffusion constant in r-space, Dp, or the attempt rate density, Vq. These parameters are hard to establish from first principles. For instance, the rate of critical pore appearance, v, is described in Ref. 75 through an Arrhenius equation ... 

Bockmann, R.A., de Groot, B.L., Kakorin, S., Neumann, E., Grubmuller, H. Kinetics, statistics, and energetics of lipid membrane electroporation studied by molecular dynamics simulations. Biophys. J. 2008, 95, 1837-50. 

Tarek, M. Membrane electroporation a molecular dynamics simulation. Biophys. J. 2005, 88, 4045-53. 

The electrochemical interface between biomolecules cellular membranes, transmembrane potentials, bilayer lipid membranes, electroporation... 

Electroporation — (depending on the system under study also called membrane electroporation). An electric field applied to a -> membrane or on a larger scale to an area of skin changes the permeability of the mem-brane/skin for molecular substances (or in the latter case... 

Nanda, G.S., Bedekar, V.W., and Mishra, K.P., Biomedical potential of cell membrane electroporation. Proceedings of 2nd Biomedical Symposium, BARC, Mumbai, 1994. 

Chapter 26 Membrane Electroporation and Emerging Biomedical Applications.741... 

Above some electroporation threshold, the transmembrane potential cannot be further increased, and can even decrease due to transport of ions across the membrane [91, 95]. The phenomenon of membrane electroporation can also be understood in terms of tension. If the total membrane tension exceeds the lysis tension c ys, the vesicle ruptures. This corresponds to building up a certain critical transmembrane potential, = Pc- According to Eqs. (7.3) and (7.4), this porahon potenhal Pc depends on the inihal membrane tension Co as previously reported [59, 89, 90, 96, 97]. The crihcal hansmembrane potenhal for cell membranes is about IV (e.g., [98, 99]). 

Neumann, E., Kakorin, S., and Toensing, K. (1998) Membrane electroporation and electromechanical deformation of vesicles and cells. 

Kakorin, S. and Neumann, E. (2002) Electrooptical relaxation spectrometry of membrane electroporation in lipid vesicles. Colloids and Surfaces A, IW (2-3), 147-165. 

---