Melanocyte stimulating hormone a-MSH

The anorexigenic (appetite-suppressing) neurons in the arcuate nucleus produce a-melanocyte-stimulating hormone (a-MSH), formed from its polypeptide precursor pro-opiomelanocortin (POMC Fig. 23-6). Release of a-MSH causes the next neuron in the circuit to send the signal to the brain, Stop eating ... 

Penny RJ, Thody AJ (1978) An improved radioimmunoassay for a-melanocyte-stimulating hormone (a-MSH) in the rat serum and pituitary a-MSH levels after drugs which modify catecholamine neurotransmission. 

MA-TR, monoamine transporter MCP-1, monocyte chemoattractant protein 1 MG-R, a-melanocyte-stimulating hormone (a-MSH) receptor MD, methylenedioxy... 

This section concludes with two examples of semi-synthesis catalysed by pro-teinases. The first case concerns the semi-synthesis of a-melanocyte stimulating hormone (a-MSH) from two fragments that had been made by chemical synthesis (Scheme 7.16). There are three interesting points to notice. One of the fragments was made by SPPS using a polystyrene resin containing a 4-nitrobenzophenone moiety,... 

Proteins may be acetylated, usually on the a-amino group s TV-terminal residue but occasionally on the e-amino group of a lysine residue. Acetylation is effected with acetylcoenzyme A (8.3), although other biochemical acetylating agents are well known. a-Melanotropin or a-melanocyte-stimulating hormone (a-MSH) provides an example of post-translational acetylation ... 

The major opioid peptide derived from POMC is /5-endorphin. In addition to /5-endorphin, the POMC precursor also is processed into the nonopioid peptides adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (a-MSH), and /5-lipotropin /5-LPH). Proenkephahn contains multiple copies of met-enkephalin, as well as a single copy of leu-enkephalin. Prodynor-phin contains three peptides of differing lengths that aU begin with the leu-enkephalin sequence dynorphin A, dynorphin B, and neoendorphin (Eigure 21-1). 

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