Medium level investigations

A medium level investigation will involve a more detailed investigation by the relevant supervisor or line manager, the health and safety adviser and employee representatives and will look for the immediate, underlying and root causes... 

The use of the modelling-based strategy above described was investigated from an action research perspective by one of us (PF) who was the chemistiy teacher of a first grade medium level school class of 26 students (14-15 years old) in Brazil. 

In order to exclude the aforementioned detrimental effects of both high disperse phase content as well as high emulsion viscosity on flie influence of the viscosity ratio, a second fanuly of emulsions was employed. For these, the total viscosity of the silicone oil emulsions was kept at a constant, medium level. The viscosity ratio was then varied by using silicone oils with different oil viscosities. Taking the results of Fig. 21.46 into account, the disperse phase content was set to 1 wt% so that its influence on the measurements (e.g., via increased coalescence) was negligible. Three different viscosity ratios were investigated which were aU nearly unity to assure a good transfer of the stresses oti the oil drops. 

Immediate hypersensitivity reactions to RCM are associated with histamine release from basophils and mast cells [27], and extensive mast cell activation in vivo associated with clinical symptoms has been demonstrated by Earoche et al. [31]. Patients with hypersensitivity reactions after contrast medium exposure had increased plasma levels of both histamine and tryptase, and levels correlated with severity. Also other investigators have reported high levels of tryptase in connection with severe or fatal reactions [21, 33]. 

All of the above may appear to involve a great deal of effort but the extent of the effort should be based on the level of risk involved. The starting point should therefore be a risk-based assessment, categorizing the systems as high, medium or low risk based on their impact on the quality of the final result. Electronic records that are generated by systems that are critical to the study should be examined in detail for the whole of their life cycle. The following process is a way to approach the risk-based investigation ... 

Initially, the level of theory that provides accurate geometries and bond energies of TM compounds, yet allows calculations on medium-sized molecules to be performed with reasonable time and CPU resources, had to be determined. Systematic investigations of effective core potentials (ECPs) with different valence basis sets led us to propose a standard level of theory for calculations on TM elements, namely ECPs with valence basis sets of a DZP quality [9, 10]. The small-core ECPs by Hay and Wadt [11] has been chosen, where the original valence basis sets (55/5/N) were decontracted to (441/2111/N-11) withN = 5,4, and 3, for the first-, second-, and third-row TM elements, respectively. The ECPs of the second and third TM rows include scalar relativistic effects while the first-row ECPs are nonrelativistic [11], For main-group elements, either 6-31G(d) [12-16] all electron basis set or, for the heavier elements, ECPs with equivalent (31/31/1) valence basis sets [17] have been employed. This combination has become our standard basis set II, which is used in a majority of our calculations [18]. 

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