Medicinal chemistry, matrix

Verma, R. P. and Hansch, C. (2007) Matrix metalloproteinases (MMPs) chemical-biological functions and (Q)SARs. Bioorganic Medicinal Chemistry, 15, 2223-2268. 

Jacobson, I. C., Reddy, P. G., Wasserman, Z. R., et al. (1998) Structure-based design and synthesis of a series of hydroxamic acids with a quaternary-hydroxy group in PI as inhibitors of matrix metalloproteinases. Bioorganic Medicinal Chemistry Letters, 8, 837-842. 

Breyholz, H.-J., Schafers, M., Wagner, S., et al. (2005) C-5-disubstituted barbiturates as potential molecular probes for noninvasive matrix metalloproteinase imaging. Journal of Medicinal Chemistry, 48, 3400-3409. 

Groneberg, R. D., Bums, C. J., Morrissette, M. M., et al. (1999) Dual inhibition of phosphodiesterase 4 and matrix metalloproteinases by an (arylsulfonyl)hydroxamic acid template. Journal of Medicinal Chemistry, 42, 541-544. 

Caldarelli, M., Habermann, J. and Ley, S.V. (1999) Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of pol3Tner-supported reagents. Bioorganic Medicinal Chemistry Letters, 9, 2049-2052. 

The combination of matrix library data and additivity analysis informs on the limitations of certain QSAR analysis, and aids in prospective library design. The use of additivity theory as applied to library design will be discussed in the context of specific medicinal chemistry examples. 

In fact, other mt-QSAR approaches, with demonstrated usefulness, have been introduced recently in medicinal chemistry (Gonzdlez-Dfaz et al. 2006 Marrero-Ponce et al. 2004 Molina et al. 2004). A Markov Model encoding molecular backbones information was introduced in the method named the MARCH-INSIDE, MARkovian CHemicals IN Sllico DEsign (Gonzdlez-Dfaz et al.). This method allows one to introduce matrix invariants such as stochastic entropies. 

Marrero-Ponce, Y., Diaz, H. G., Zaldivar, R, Torrens, V. R.. 8cCastro. E. A. (2004). 3D-Chiral quadratic indices of the molecular pseudograph s atom adjacency matrix and their application to central chirality codification classification of ACE inhibitors and prediction of cr-receptor antagonist activities. Bioorganic Medicinal Chemistry, 12, 5331. 

Mendis, E Kim, MM Rajapakse, N Kim, SK. Carboxy derivatized glucosamine is a potent inhibitor of matrix metalloproteinase-9 in HT1080 cells. Bioorganic Medicinal Chemistry Letters, 2006, 16, 3105-3110. 

Polyoxometalates have found applications in analytical and clinical chemistry, catalysis (including photocatalysis), biochemistry (electron transport inhibition), medicine (antitumoral, antiviral, and even anti-HIV activity), and solid-state device [19,20], Recently, three-dimensional ordered materials are modified by the incorporation of POM into wall structures using a direct synthesis approach [21,22], The motivation for the work lies in the novel properties that POM is introduced into silica networks [19,20], The incorporation is that the POM is linked to silica matrix by covalent grafting. A class of POM that are particularly attractive for the preparation of hybrid materials are the lacunary POM. Lacunary POMs include the mono and divacant unsaturated Keggin fragments [X" W,039]< ">- (X"+=B Ge P [22], [ Y -SiWioOgg] [21], Lacunary... 

Beate Kehrel studied biology and chemistry at the University of Muenster. After her Ph. D., die studied medicine and started her scientific career at the Institute for Arteriosclerosis Research in Muenster., where she came in-now 15 years ago-into initial contact with her main field of research., the interaction of platelets and extracellular matrix, especially collagen. After woridng for 12 years on thrombocytopathias in the Department of hitemal Medicine at the University of Muenster, she is now Head of the Laboratoriesfor Experimental and Clinical Haemostaseology in the Department of Anaesthesiology. 

The phrase invention of chemistry as a discipline is on 153. As Frederic L. Holmes noted, a work prior to Hannaway s had identified the emergence in the early eighteenth century of a science of chemistry. .. from the matrix of natural philosophy, medicine, alchemy, and technology. This was Robert P. Multhauf s The Origins of Chemistry (New York Franklin Watts, 1966), 349. See Frederic L. Holmes, Concepts, Operations, and the Problem of Modernity5 in Early Modern Chemistry, Fundamental Concepts of Early Modern Chemistry in the Context of the Operational and Experimental Practice (Berlin Max Planck Institute, 1995 [Preprint 25]), 50. 

Scientific workers of the Institute of Surface Chemistry of the NAS of Ukraine and the Vinnytsya State Medical University have designed a new enterosorbent Silics and introduced it into medicinal practice. The enterosorbent is a synthetic amorphous highly disperse silica (HDS). Owing to salient features of its surface, HDS is employed not only as a sorbent with biocorrecting properties but also as a matrix used in the capacity of a carrier of composite medicinal agents [1]. 

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