Medicinal chemistry , drug discovery

Blagg, J. (2010) Structural alerts for toxicity, in Burger s Medicinal Chemistry, Drug Discovery and Development, Discovery of Lead Molecules, vol. 2, 7th edn... 

William J. Coates, David J. Hunter and William S. Macirachlan, Successful implementation of automation in medicinal chemistry. Drug Discovery Today, 5 (2000), 521-527. 

Rzeszotarski WJ. Alzheimer s disease search for therapeutics. In Abraham DJ, ed., Burger s Medicinal Chemistry Drug Discovery, voi... 

Blagg, J. Structural Alerts For Toxicity. In Burger s Medicinal Chemistry, Drug Discovery, and Development, Seventh Edition-, Abraham, D. J. Rotella, D. P., Eds. Wiley Hoboken, NJ, 2010 pp 301-334. 

Selassie C, Verma RP (2010) History of quantitative structure-activity relationships. In Abraham D (ed) Burger s medicinal chemistry, drug discovery and development. Wiley, New YotIc, pp 1—95... 

Maloney, T.P., Kaba, R.A., Krueger, J.P., Kratz, R., and Mitchell, C.J. (2003) Intellectual property in drug discovery and biotechnology, in Burgefs Medicinal Chemistry, Drug Discovery and Development, vol. 3 (eds D.J. Abraham and D.P. Rotella), John Wiley Sons, Inc., Hoboken, NJ, pp. 101-186. 

Lin, J. H., Ostovic, D. and Vacca, J. P. The integration of medicinal chemistry, drug metabolism and pharmaceutical research and development in drug discovery and development story of Crixivan, an HIV protease inhibitor, Pharm. Biotechnol. Integration of Pharmaceutical Discovery and Development, 11 233-255. 1998. 

In general, homogeneous methods are preferable due to their simplicity and kinetic methods are preferable due to their enabling kinetic features. Until recently, the only mixture-based heterogeneous method with comprehensive kinetic capabilities was SPR. In this chapter, kinetic capillary electrophoresis (KCE) is described as a conceptual platform for separation-based homogeneous methods with comprehensive kinetic capabilities, which will find multiple applications in chemistry, biology, medicine, and drug discovery. 

Kubinyi H 1995. The Quantitative Analysis of Structure-Activity Relationships. In Wolff M E (Editor) Burger s Medicinal Chemistry and Drug Discovery. 5th Edition, Volume 1. New York, John Wiley Sons, pp. 497-571. 

A meaningful dialogue between chemists and pharmacologists is the single most important element of the drug discovery process. The necessary link between medicinal chemistry and pharmacology has been elucidated by Paton [2] ... 

Dyason JC, Wilson JC, Von Itzstein M. Sialidases Targets for rational drug design. In Bultinck P, De Winter H, Langenaeker W, Tollenaere JP, editors. Computational medicinal chemistry for drug discovery. New York Dekker, 2004. 

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