Medicinal chemistry of drugs

Relevant authors of scientific articles can join your network. Their names appear in journals of medicinal chemistry, of drug discovery and development, and of process chemistry. The first page of each article states the writers names, affiliations and surface-mailing addresses. Sometimes the article includes the senior author s e-mail address, often in a footnote on the first page. However, lists of article authors, which frequently include both chemists or biologists, do not indicate the name of the science they practice. But a telephone call to an author rather than a persormel department can elicit this information. 

Kubinyi H 1995. The Quantitative Analysis of Structure-Activity Relationships. In Wolff M E (Editor) Burger s Medicinal Chemistry and Drug Discovery. 5th Edition, Volume 1. New York, John Wiley Sons, pp. 497-571. 

Muller G. Medicinal chemistry of target family-directed masterkeys. Drug Discov Today 2003 8 681-91. 

Organic phosphates, phosphonates, and analogues are of interest in medicinal chemistry as drugs or prodrugs, and in toxicology mainly as plasticizers, insecticides, or warfare agents. Their breakdown by enzymatic routes has received marked attention since many years, but it is most unfortunate for the advancement of science that an unknown number of highly relevant results remain classified information. 

Not unexpectedly, cycloalkene oxides are equally important as alkene oxides in medicinal chemistry and drug metabolism, as illustrated below with a few selected examples. Other compounds of interest that will not be discussed here include epoxytetrahydrocannabinols and endogenous 16,17-ep-oxy steroids. 

Criteria for Inception of a Medicinal Chemistry-Led Drug Discovery Project... 

Abraham, D.J. (Ed.). History of quantitative structure activity relationships. In Burger s Medicinal Chemistry and Drug Discovery, Volume 3. John Wiley Sons, Hoboken, NJ, 2003, 1-48. Chapters by Selassie, C.D. Tropsha, a. Recent trends in quantitative stmcture-activity relationships, 49-76 Marshall, G.R. Beusen, D.D. Molecular modeling in drug design, 77-168 ... 

In Chapter 1, John Lowe details The Role of Medicinal Chemistry in Drug Discovery in the twenty first century. The overview should prove invaluable to novice medicinal chemists and process chemists who are interested in appreciating what medicinal chemists do. In Chapter 2, Neal Anderson summarizes his experience in process chemistry. The perspectives provide a great insight for medicinal chemists who are not familiar with what process chemistry entails. Their contributions afford a big picture of both medicinal chemistry and process chemistry, where most of the readers are employed. Following two introductory chapters, the remainder of the book is divided into three major therapeutic areas I. Cancer and Infectious Diseases (five chapters) II. Cardiovascular and Metabolic Diseases (six chapters) and III. Central Nervous System Diseases (four chapters). 

The medicinal chemistry of fluorosteroids is of course dominated by the fluoro-corticoids. Research in fluorocorticoids is now essentially devoted to the search for new formulation of registered drugs. Elsewhere, there is currently a renewal of interest for fluorosteroids in medicinal chemistry mainly in view to develop drugs for hormonal disorders. 

Part I described the basics of medicinal chemistry and drug design. These principles follow three basic activities ... 

Since these two classes of corticosteroids are both important in medicinal chemistry and drug design, they will be discussed separately. 

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