Medical applications cross-linking method

In the literature several methods to chemically modily poly(styrene) have been reported. The interest in the surface functionalization stems from the need to improve cell adhesion on PS petri-dishes for medical and biological applications, while PS cross-linking techniques were investigated for potential application as lithography resist. However, only two of the numerous reported techniques proved to be effective and suitable for the mesoporous styrenic templates, namely exposure to ozone or plasma ignited in several atmospheres, such as nitrogen, air, oxygen, and water vapor. 

This chapter focuses on two subjects related to the field of mechanically stimulated reactions (1) chemical and photochemical CTOss-linking of HA in aqueous solutions and (2) advanced methods of solid-phase polysaccharide modification. From these processes, the cross-linked hyaluronic hydrogels acquire a number of valuable properties that significantly extend the range of their medical applications. 

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