Meclofenoxate hydrochloride

Otsuka T, Yoshioka S, Aso Y, Terao T. Application of microcalorimetry to stability testing of meclofenoxate hydrochloride and DL-ot-tocopherol. Chem Pharm Bull 1994 42(1) 130-132. 

There are only a few reports in the literature on the use of isothermal microcalorimetry for the stability testing of pharmaceuticals (although in other fields, such as explosives, there are many more references testifying to a good degree of success). These include the degradation of P-lactam antibiotics (7), the oxidation of lovastatin (8), the hydrolysis of meclofenoxate hydrochloride (9), and the oxidation of d,l-a-tocopherol (10). 

Equation (2.57) is equivalent to Eq. (2.55) when 1 and m equal zero. Equation (2.58), obtained by integrating Eq. (2.57), describes the initial hydrolysis rate of meclofenoxate hydrochloride in the solid state.272-273 Similarly, this equation describes the hydrolysis of propantheline bromide under high-humidity conditions, as shown in Fig. 22.274 Equation (2.58) has also been applied to the initial degradation of aspirin derivatives in the solid state (Fig. 23).275... 

The effect of humidity on the solid-state degradation rates of propantheline bromide and meclofenoxate hydrochloride has been described by... 

S. Yoshioka, T. Shibazaki, and A. Ejima, Stability of solid dosage forms. I. Hydrolysis of meclofenoxate hydrochloride in the solid state, Chem. Pharm. Bull. 30, 3734-3741 (1982). 

C4H10CIN 107-99-3) see Bephenium hydroxynaphthoate Binedaline Brompheniramine Captodiame Carbinoxamine Chlorphenamine Chlorphenoxamine Cyclopentolate Dibenzepine Diltiazem Dimetindene Doxylamine Ethoheptazine Itopride hydrochloride Meclofenoxate Mepyramine Moxisylyte Normethadone Noxiptiline Pheniramine Phenyltoloxamine Tamoxifen Toremifene Trimethobenzamide Tripelennamine Zotepine... 

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