Mechanism of toxicologic action

Conduct additional mechanism of toxicologic action studies, if necessary. 

Every scientific discipline has its problems and pit-falls and biohemistry is no exception. Most of those discussed by Dr. Waggoner may not seem new. Maybe that is a reason they are still problems and pitfalls. One pitfall is the often lack of coordinate planning, especially between the fields of chemistry and toxicology. An example of this is the minor effort in defining the mechanism of toxicological action. Is the pressure to meet regulatory needs a cause of this Such pressure could even be the reason for minimal... 

C. I Mechanism of toxicologic action. PBBs are believed to activate ribonucleic acid (RNA)... 

Special tools are needed to study those underlying processes, and a significant fraction of scientists in the toxicology community are involved in such research. Sometimes the phrase mechanism of toxic action is used to describe these various underlying processes, although it is often used to describe only the pharmacodynamic piece of the picture. It is extraordinarily difficult to uncover all relevant mechanistic processes, but significant pieces of the puzzle of toxicity are known for many substances. 

Lugovskoy SP, Legkostup LA (2002) Mechanism of biological action of lead on digestive system. Sovremennye Problemy Toksikologii (Russian Modern Problems of Toxicology ) 2 45-50... 

Investigative toxicology Determine sequence and mechanisms of toxic action. Discover the genes, proteins, pathways involved. Develop new methods for assessing toxicity use computer-assisted modeling. 

Casida J.E., (2010) Pest toxicology the primary mechanisms of pesticide action, in Handbook of Pesticide Toxicology,... 

Gene structure and any of the processes involved in DNA expression including transcription, mRNA processing and translation and protein synthesis (Figure 2.2) can all be examined by molecular techniques. In toxicology this may include toxic effects on these processes or the role of the processes in the mechanism of toxic action. 

CAPEN, C.C. (1996) Toxic responses of the endocrine system. In Cassarett and Doull s Toxicology, The Basic Science of Toxicology, edited by C.D.Klaassen, 5th edition (New York McGrawHill). COULSON, C.J. (1994) Molecular Mechanisms of Drug Action, (London Taylor Francis). DEKANT, W. and VAMVAKAS, S. (1993) Glutathione-dependent bioactivation of xenobiotics. 

---