Mecamylamine

CHN 74-90-8) see L-Alanine Alfentanil Dimethadione Edetic acid Ibuprofen Indanorex Mecamylamine Molsidomine Nadoxolol D-Penicillamine Phensuximide L-Tryptophan Vetrabutine hydrogen peroxide... 

Rohsenow DJ, Monti PM, Colby SM, et al Naltrexone treatment for alcoholics effect on cigarette smoking rates. Nicotine Tob Res 5 231-236, 2003 Rose JE, Levin ED Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence. Pharmacol Biochem Behav 41 219—226, 1991 Rose JE, Behm FM, Westman EC, et al Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicontine patch treatment alone. Clin Pharmacol Ther 56 86-99, 1994... 

Rose JE, Behm FM, Westman EC Nicotine-mecamylamine treatment for smoking cessation the role of pre-cessation therapy. Exp Clin Psychopharmacol 6 331-343, 1998... 

Mechanical Response. PTX (5 x 10" to 3 x 10 M) caused a concentration-dependent contraction of the guinea pig vas deferens. The configuration of contractile response indicated the presence of two components, an initial rapid component followed by a second slow component. The first component of the response to PTX was abolished after treatment with Mg (10 mM), Ca -free medium, or ouabain (10 M), but remained almost unaffected by phentolamine (10 M), reserpine, 6-OHDA, atropine, or mecamylamine (10" M). The second component of the response to PTX was also completely inhibited after the incubation in the high or Ca -free medium. Phentolamine, reserpine, or 6-... 

A combination of the nicotine antagonist mecamylamine and bupropion (Quitpack )... 

Mihailescu S., Palomero-Rivero M., Meade-Huerta P., Maza-Flores A., Drucker-Colin R. (1998). Effects of nicotine and mecamylamine on rat dorsal raphe neurons. Eur.. Pharmacol. 360, 31-6. 

Nicotine increased DA levels both in vivo11,193 and in vitro. 94 196 Nicotine197 and its metabolites198 were found to both release and inhibit the reuptake of DA in rat brain slices, with uptake inhibition occurring at a lower concentration than that required for DA release. In addition, the (-) isomer was more potent than the (+) isomer.197 However, the effects of nicotine upon DA release and uptake were only apparent when brain slices were utilized because nicotine was unable to affect DA when a synaptosomal preparation was utilized.197 These results indicate that nicotine exerts its effects upon the DAT indirectly, most likely via nicotine acetylcholine receptors. This finding was supported by the results of Yamashita et al.199 in which the effect of nicotine on DA uptake was examined in PC 12 and COS cells transfected with rat DAT cDNA. Nicotine inhibited DA uptake in PC 12 cells that possess a nicotine acetylcholine receptor. This effect was blocked by the nicotinic antagonists hexamethonium and mecamylamine. Additionally, nicotine did not influence DA uptake in COS cells, which lack nicotinic acetylcholine receptors. 

Dixon JMS, Paulley JW Bacteriological and histological studies of the small intestine of rats treated with mecamylamine. Gut 1963 4 169-173. 

P6. Paulley, J. W., and Dixon, J. M. S., Small gut bacterial and histological studies in mecamylamine-induced ileus in rats. Symposium on Malabsorption Syndrome, Proc. 2nd World Congress Gastroenterology, Munich, 1962. 

Lobeline also increases basal release of norepinephrine, but norepinephrine release may be reduced at higher lobeline concentrations (Rao et al. 1997). Unlike acetylcholine, lobeline does not reduce the release of dopamine or norepinephrine by NMDA receptors, but it does block nicotine-induced release of norepinephrine from the locus coeruleus (Gallardo and Leslie 1998). Lobeline also evokes release of serotonin, which is mediated by uptake transporters and unaffected by mecamylamine (Lendvai et al. 1996). 

An acute dose of lobeline impairs attention in one animal model, but not as much as mecamylamine (Turchi et al. 1995). Lobeline improves memory when administered after a passive avoidance paradigm (Decker et al. 1993). Pretreatment with lobeline improves performance in rats with septal lesions on a spatial discrimination water maze. Lobeline is about one-tenth as potent as nicotine in the passive avoidance memory task, but equivalent to nicotine in the water maze. 

Cognitive effects Animais Cognitive effects of nicotine have been observed in several species, including humans. Experimental studies have focused primarily on the effects on attention and memory. Cognitive benefits are seen after both acute and chronic administration (Levin et al. 1992). In experimental animals, nicotine improves learning and memory on a variety of tasks. Conversely, the nicotinic antagonist mecamylamine... 

Hildebrand BE, Nomikos GG, Hertel P, SchEstrom B, Svensson TH. 1998. Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Brain Res 779(1—2) 214-225. 

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