Maturity chain process

To maximize (1/e) becomes a modem need that invites conscious effort from all of us who write, issue, or edit papers, reports, reviews, etc. We believe it to be a major goal for a publication such as ours to integrate information effectively and with mature criticality to present that which orients and instructs concerning the state of the current boundary of knowledge, and which thereby may significantly influence the propagative chain process of evolving our science. 

Supply chain excellence is defined by the ability to use the supply chain to deliver the business strategy. The maturity of process allows companies to improve the potential of the supply chain to maximize opportunity and mitigate risks while raising the effective frontier. 

To be effective at market sensing, companies have to build strong horizontal processes to connect downstream and upstream data. Traditionally, supply chain processes have evolved from vertical processes. These functional silos—source, make, and deliver—gave birth to supply chain management. However, this silo approach, and a focus on vertical excellence, is both a barrier and an enabler to maximize value and build strong networks. It is a conundrum. Companies need to build strong vertical silos to deliver operational excellence but at some point in their maturity, they must "break the glass" and shift their focus to build horizontal excellence. 

The term S OP is 30 years old. However, as supply chain processes have matured, this term has been redefined. Today, companies are at one of five stages of maturity. Each stage offers increasing opportunity and ROI. 

One of the reasons that S OP is so important is the benefit that it has across a range of metrics. While many supply chain processes will improve one to two metrics, the benefits of improving S OP maturity are pervasive touching many metrics and raising the bar of total performance. 

The literature on the topic presents a number of supply chain maturity models. Such models most often facilitate the analysis of the status quo in supply chain processes they also constitute a source of guidelines for the improvement of these processes, thus helping in reaching higher levels of supply chain excellence. Models fulfilling the objectives specified above include ... 

Table 2.5 Maturity level of selected supply chain processes in Poirier s model...

A completely distinct enzyme has been found in a number of organisms, which carry out the metabolism of amino acids. In this group, a pyruvoyl group is covalently bound to the active enzyme that is produced from a proenzyme in a self-maturation process (Toms et al. 2004). The proenzyme contains a serine residue that undergoes rearrangement to an ester followed by conversion into the (3-chain of the enzyme and a dehydroalanine residne that forms the A-terminal pyruvoyl group of the a-chain. This type of enzyme has been fonnd for a number of important decarboxylations ... 

It has long been known that peptides of bacterial origin, such as N-formylat-ed oligopeptides, are potent activators of neutrophils. Bacterial protein biosynthesis is initiated by the codon AUG, which codes for polypeptide chains at the NH2 terminus to start with N-formylmethionine. However, very few mature bacterial proteins actually have this amino acid at the NH2 terminus because Af-formylmethionine is cleaved off by proteolytic processing. Sometimes just this amino acid is cleaved, but often several adjacent residues are also removed with it. These observations formed the basis for the chemical synthesis of a variety of N-formylated oligopeptides and an assessment of their ability to activate neutrophils in vitro. The most potent of these formylated peptides is TV-formylmethionyl-leucyl-phenylalanine (fMet-Leu-Phe). 

---