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Mastocytosis skin lesions

The most important survival and growth factor for mast cells is the KIT Ugand stem cell factor (SCF) [12], The hypothesis of early studies, that SCF might be elevated in skin lesions associated with mastocytosis [13], however, was not confirmed by later studies on SCF levels in skin and blood, at least for adult patients [14],... [Pg.111]

Florian S, Krauth MX, Simonitsch-Klupp I, et al Indolent systemic mastocytosis with elevated serum tryptase, absence of skin lesions, and recurrent severe anaphylactoid episodes. Int Arch Allergy 43 Immunol 2005 136 273-280. [Pg.124]

Dermographic urticaria is the most frequent form of physical urticaria, and it is characterised by the development of wheals in those sites exposed to even mild traumas (scratching, rubbing, etc.). Moreover, a typical dermographic reaction is present in the case of mastocytosis, even in the absence of apparent skin lesions. [Pg.363]

Mastocytomas and diffuse cutaneous mastocytosis are further manifestations of cutaneous mastocytosis (CM) [9]. Solitary mastocytomas are common in children. Most are present at birth or develop in infancy. These lesions are flat or mildly elevated, well demarcated, solitary yellowish red-brown plaques or nodules, typically 2-5 cm in diameter. Diffuse cutaneous mastocytosis is a rare disorder characterized by diffuse mast cell infiltration of large areas of the skin that presents in infants in the first year of life. Severe edema and leathery indurations of the skin leads to accentuation of skin folds (pseudo-lichenified skin) and a peau-dbrange-like appearance. Systemic complications include hypotension and gastrointestinal hemorrhage. Infants and young children with considerable mast cell infiltration of the skin sometimes exhibit blister formation in the first 3 years of life. MPCM and other forms of CM have been classified in a consensus nomenclature (table 1) [10]. [Pg.113]

Mastocytosis is recognized in most patients because of the presence of characteristic cutaneous lesions [10]. A positive Darier s sign and/or histological examination of the skin using metachromatic stains, or by immunohistochemistry using antibodies to mast cell tryptase, helps confirm the diagnosis of cutaneous disease. [Pg.118]


See other pages where Mastocytosis skin lesions is mentioned: [Pg.110]    [Pg.119]    [Pg.121]    [Pg.122]    [Pg.112]    [Pg.115]   
See also in sourсe #XX -- [ Pg.121 , Pg.122 ]




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