Mass time-resolved atmospheric pressure

Most ion-molecule techniques study reactivity at pressures below 1000 Pa however, several techniques now exist for studying reactions above this pressure range. These include time-resolved, atmospheric-pressure, mass spectrometry optical spectroscopy in a pulsed discharge ion-mobility spectrometry [108] and the turbulent flow reactor [109]. 

C. The Time-Resolved Atmospheric Pressure Ionization Mass Spectrometer (TRAPI)... 

Note The acronyms used here are OSPED (optical spectroscopy in a pulsed electrical discharge), FAMS (flowing afterglow mass spectrometry), SIFT (selected ion flow tube), TRAPI (time-resolved atmospheric pressure ionization mass spectrometry), PHPMS (pulsed high-pressure ionization mass spectrometry), ICRMS (ion cyclotron resonance mass spectrometry), and ADO (averaged dipole orientation collision rate theory). 

Oh, J.-S., Aranda-Gonzalvo, Y., Bradley, J.W. (2011) Time-resolved Mass Spectroscopic Studies of an Atmospheric-pressure Helium Microplasma Jet. J. Phys. D Appl. Phys. 44 365202. 

Bradykinin was used as an analyte in the investigation and optimization of the TLC-MALDI coupling protocol. In this protocol, a matrix solution (a-cyano-4-hydroxycinnamic acid) was deposited onto a stainless steel or polyester plate. The resolved TLC plate was sprayed with extraction solvent and placed into a solvent-saturated atmosphere. Afterward, the stainless steel or polyester plate was placed face-to-face with the dampened TLC plate and pressed. The pressing step puts pressure on the stationary phase, forcing solvent toward the top surface of the TLC plate and the matrix layer and also transfers the matrix to the top of the TLC plate. After removal of the stainless steel or polyester plate, the matrix remains on the TLC plate cocrystallized with analyte. The TLC plate is then analyzed in a MALDI mass spectrometer. According to the discussed paper, the parameters of the TLC-MALDI coupling protocol, particularly for the extraction solvent selection, extraction time and pressure have been investigated and optimized [25]. 

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