Mass spectrometry research

It should be noted that advances and progress in life sciences, including the study of biological processes would not have been possible without the use of the powerful analytical techniques of mass spectrometry. Research developments in mass spectrometry are increasingly driven by research demands in the life sciences including the huge field of biology. 

Department of Biochemistry Mass Spectrometry Research Center Vanderbilt University Medical Center Nashville, Tennessee... 

This chapter is divided into three sections. Section 1 covers the electron ionization (El) mass spectra of acetylenic compounds and discusses the types of singly and doubly charged cations formed on electron impact. Section 2 concerns the unimolecular chemistry of ions with C=C bonds. Finally, Section 3 is devoted to the ion-molecule reactions of acetylenic ions and acetylenes. The material mainly originates from articles that have been published within the last decade and is presented with considerable detail. This review does not claim to be exhaustive nevertheless, it provides examples from all areas of active mass spectrometry research in C=C bonded molecules, so that the reader can learn about the important and novel developments in this area. 

Peggi M. Angel Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, USA... 

Catania (Italy) Author of more than 50 publications and of 18 international invited lectures. He is currently working in the field of characterization of polymers and copolymers. He is an editorial board member of Rapid Communications in Mass Spectrometry. Research interests Structural characterization of polymers by mass-spectrometric techniques MALDI for the analysis of polymers and copolymers chain statistics applied to copolymer sequence analysis MonteCarlo simulations Bivariate distributions of chain size, and composition in high conversion copolymers. 

In the early days of mass spectrometry, research was focused on gas source isotope ratio mass spectrometry (IRMS) or thermal ionization mass spectrometry (TIMS), with as the main aim the determination of the isotopic composition and molar masses of the elements. Since the 1940s, isotope ratio measurements have also been used for the determination of isotope ratios involving a radiogenic nuclide and for quantitative element determination via isotope dilution (see also Chapter 8). The age of the solar system and the Earth were also of particular interest within isotope ratio science. With the establishment and improvement of TIMS instrumentation, the awareness of the importance of precision and accuracy and the need to be able to reproduce a result in another laboratory grew, while... 

Mass Spectrometry Research Center Departments of Chemistry and Biochemistry... 

Figure 18.6 Mass analyzers employed in imaging mass spectrometry research. A schematic representation of the NanoSIMS magnetic/ electric sector mass analyzer is depicted in the left-hand panel (http //www.cameca.fr/html/ product nanosims.html). A ToF mass analyzer...

Yuko Fukuyama Koichi Tanaka Mass Spectrometry Research Laboratory,... 

The author thanks Shimadzu Corporation. The author also thanks Koichi Tanaka, Shinichi Iwamoto, Helen Montgomery and staff of Koichi Tanaka Mass Spectrometry Research Laboratory for thoughtful consideration and helpful comments, and Sadanori Sekiya and Kaoru Kaneshiro for providing figures for this chapter. 

This overview covers relevant issues in instrumentation for modern mass spectrometry, an overview of techniques used in both classical and newer areas of mass spectrometric investigation and a preview of growth areas in mass spectrometry research and application. Current applications are best reviewed by examination of the manuscripts published in the current journals of mass spectrometry, and review of the papers presented at the annual professional meetings, especially meetings dealing with biological chemistry, and the annual meetings of the American Society for Mass Spectrometry. 

Since 1990, EPO has been prohibited by the IOC and WADA, and a study published by Videman in 2000 stressed the rationale a considerable increase of total hemoglobin mass in elite cross country skiers has been measured since recombinant EPO has become commercially available. Hence, the search for an adequate assay to determine the misuse of EPO in sports has been an important item of anti-doping research. With regard to mass spectrometry, research activities have been limited primarily due to the complexity and nearly identical... 

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