Marine samples toxicology

Moser, V.C., Cheek, B.M. MacPhail, R.C. (1995) A multidisciplinary approach to toxicological screening 111. Neurobehavioral toxicity. J. Toxicol environ. Health, 45, 173-210 Miiller-Tegethoff, K., Kasper, P. Muller, L. (1995) Evaluation studies on the in vitro rat hepatocyte micronucleus assay. Mutat. Res., 335, 293-307 Murray, H.E., Ray, L.E Giam, C.S. (1981) Phthalic acid esters, total DDTs and polychlorinated biphenyls in marine samples from Galveston Bay, Texas. Bull, environ. Contam. Toxicol, 26, 769-774... 

In work related to the human toxicology of arsenic, Cox (5) noted that within 24 hours after a person eats fish, arsenic can be measured in the urine at levels normally indicative of chronic arsenic poisoning. The subsequent study of Chapman (6) in 1926 established the occurrence of high levels of arsenic in a wide range of marine organisms. Arsenic concentrations in seawater were also reported at this time (7). Over the ensuing years there followed only infrequent reports (e.g., 8) on arsenic in marine samples until the late 1960s. Renewed interest... 

Obana, H., S. Hori, and T. Kashimoto. 1981a. Determination of polycyclic aromatic hydrocarbons in marine samples by high-performance liquid chromatography. Bulletin of Environmental Contamination and Toxicology 26 613-620. 

The accuracy of this type of simultaneous spedes-spedfic multi-element GC-ICP-IDMS determination of five elemental species of high relevance for toxicological assessment of marine food samples was demonstrated by the excellent agreement of the results obtained with the corresponding certified values for different reference materials. LCDs of 1.4 ng g for MMM, 0.06 ng g for TML, 1.2 ng g for DBT, and 0.3 ng g for MBT and TBT were obtained, which are much lower than the limits required for adequate control of seafood. The tolerable weekly intake of MMM for humans as recommended by the US Environmental Protection Agency (EPA) is <0.7 Jg kg body weight and the tolerable MMM content in fish as recommended by the EU is < 1 xg g . With resped to the relative simple sample preparation and the commerdal availability of certified spike solutions of MMM and the butyltin compounds, multi-spedes spedes-spedfic GC-ICP-IDMS has a high... 

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