Mammary carcinoma, estrogen dependent

Borner C, Wyss R, Regazzi R, Eppenberger U, Fabbro D (1987) Immunological quantitation of phospholipid/Ca -dependent protein kinase of human mammary carcinoma cells inverse relationship to estrogen receptors. Int ) Cancer 40 344-348... 

Davis BA and Cowing BE (2000) Pyridoxal supplementation reduces cell proliferation and DNA synthesis in estrogen-dependent and -independent mammary carcinoma cell lines. Nutrition and Cancer 38,281-6. 

While the inhibition of aromatase activity by PED is well established, some controversy exists as to its inhibition of tumor growth in vivo. Zimniski and coworkers and Puett and coworkers showed that PED was a potent inhibitor of dimethylbenzanthracene-induced mammary tumor growth at a dose of 1 mg/kg/day as well as of human ovarian carcinoma in athymic mice. In contrast, di Salle and coworkers and Zaccheo and coworkers " found that PED did not affect the growth of established tumors in the same model, nor did it prevent the appearance of new neoplasms. Thus, it appears that more in vivo studies on the inhibition of tumor growth are required before firm conclusions can be drawn on its role in estrogen-dependent tumor biology. 

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