Maltoside structure

Carbohydrate ethers, particularly methyl ethers, constitute an important class of compounds. The value of methylation studies in the structural determination of sugars is well known. The 6-, 6 -, and 3-methyl ethers of phenyl a-maltoside were needed for study of their... 

The observed differences [3] in the reactivity of primary hydroxyl groups were preparatively exploited in the structural modifications of oligosaccharides. The monomolar tritylation of phenyl a-maltoside gives the 6 - to 6- ratio of about 1.3, whereas 2.9 is observed for phenyl P-maltoside [269]. Generally, the orientation of... 

The Conformations of Methyl a-Maltoside and Related Structures, E. Alvarado, A. Ragauskas, R. U. Lemieux, and K. Bock, Abstr. Symp. on Occasion of Professor Leslie Hough receiving Claude S. Hudson Award, Third Chemical Congress of North America, Toronto, Ontario, Canada, June 5-10 (1988). 

III. Structure and Dynamics of Rhodopsin in Solutions of Dodecyl Maltoside ... 

Cysteine-scanning mutagenesis, involving more than 100 mutations, has been systematically carried out through Cl—C3, the cytoplasmic terminations of TM1-TM7, H8, and the C-terminal tail. In addition, more than 40 pairs of cysteines have been introduced at the cytoplasmic face. With these mutants as a basis set, three classes of experiments have been carried out, namely SDSL, sulfhydryl reactivity, and disulfide cross-linking kinetics. A global comparison of the results provides a unique view of the solution state, its dynamics, and its correlation with the crystal structure. By solution state is meant, in all cases, rhodopsin solubilized in dodecyl maltoside (DM) micelles. The measured functional properties of rhodopsin, namely transducin activation (Resek et al., 1993) and phosphorylation by the rhodopsin kinase (Thurmond et al., 1997), are conserved in this detergent, and it is presumed to be a reasonable approximation to the bilayer environment. 

When the true structure of these ortho ster derivatives was finally recognized, Freudenberg and Scholz reported that the new crystalline methyl maltoside heptaacetate contained one acetyl group bound differently from the other six on distillation of the substance with potassium stearate in alcoholic solution only six acetyl groups were removed in the form of ethyl acetate, which was determined quantitatively in the distillate. The presence of the seventh acetyl group was revealed by the... 

Active-site structures have been described for these related glycosylases whose reactions with maltosidic substrates and a-maltosyl fluoride proceed with retention of configuration. Their stereochemical behavior with minisubstrates of improper configuration has not been described. 

---