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Maloney murine leukemia virus

Maloney murine leukemia virus (MMLV) a vector commonly used in gene therapy (14.2) malon)l-CoAa three-carbon intermediate important in the biosynthesis of fatty acids (21.6) matrix (mitochondrial) the part of a mitochondrion enclosed within the inner mitochondrial membrane (1.6, 19.2)... [Pg.755]

The two most common are the Maloney murine leukemia virus (MMLV) and adenovirus. Both must be manipulated so that the critical genes for replication are removed and replaced with an expression cassette containing the therapeutic gene. [Pg.781]

While there may be other drawbacks associated with their use, viruses represent the most effective method for introducing exogenous DNA into eukaryotic cells. As early as the 1960s, evidence existed that viruses could be used to genetically modify cells (Friedmann, 1992). By the mid-1980s, evidence existed that nearly 100% efficiency could be obtained with available viral systems. Over the last few decades, a variety of different viruses have become common tools cited in gene therapy literature. Both retroviruses (such as Maloney murine leukemia virus, lentivirus and semliki forest virus) and DNA viruses (which include adenovirus and adeno-associated virus [AAV]) have been applied in both in vitro and in vivo gene-therapy studies. [Pg.344]


See other pages where Maloney murine leukemia virus is mentioned: [Pg.420]    [Pg.421]    [Pg.412]    [Pg.413]    [Pg.3800]    [Pg.420]    [Pg.421]    [Pg.412]    [Pg.413]    [Pg.3800]    [Pg.389]   
See also in sourсe #XX -- [ Pg.29 , Pg.127 ]

See also in sourсe #XX -- [ Pg.412 ]




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