Malaria, resistance

Acute P. falciparum malaria resistant to chloroquine should be treated with intravenous quinidine via central venous catheter and fluid status and the electrocardiogram (ECG) should be monitored closely. 

Not very long after the discovery of the deficiency of isoniazid acetylation, it turned out that the frequency of this phenotypic fault also differed much between the world s populations (47). Today, the reason for this particular interethnic variability is still unknown an influence of geographical latitude and climate is suspected. Such scientific uncertainty is common in this field of research, and it contrasts with the clear-cut findings relating malaria resistance and G-6-PD deficiency (see below). 

Fatumo S, Adebiyi E, Schramm G et al (2009) An in-silico approach to design efficient malaria drug targets to combat the malaria resistance... 

Since the early 1960s, when U S. military personnel stationed in Southeast Asia became infected with strains of malaria resistant to existing treatments, the U.S. Army s Walter Reed Army Research Institute has supported antimalarial research in its Division of Experimental Therapeutics (272). With an increase in the number of Americans traveling and living in parts of the world where such malarias are common, the public health need for new drugs has increased while pharmaceutical company interest in antimalarial R D has remained historically minimal. The Walter Reed... 

Mefloquine (also known as Lariam) came on the scene in the 1960s, and was widely used by American troops during the Vietnam War to treat chloroquine-resistant strains of P. falciparum malaria. Resistance to mefloquine, too, has developed over the years, and it remains controversial, with claims for rare but unpleasant side effects, including depression, mood disorders and permanent personality changes. 

Power, H. W., 1975, A model of how the sickle-cell gene produces malaria resistance, /. Theor. Biol 50 121. 

---