Major histocompatibility heavy chain

The major histocompatibility (MHC) class 1 molecule is composed of a heavy chain, e.g., HLA-B7, and a light chain, /32-microglobulin. To express MHC class 1, both subunits must be expressed in the same cell. The inclusion of the IRES allows both polypeptide chains of a complete MHC class I molecule to be... 

Wilson, C.M., Farmery, M. R., and Bulleid, N. J. (2000). Pivotal role of calnexin and mannose trimming in regulating the endoplasmic reticulium-associated degradation of major histocompatibility complex class I heavy chain. T. Biol. Chem. 275, 21224-21232. 

Jones TR, Sun L (1997) Human cytomegalovirus US2 destabilizes major histocompatibility complex class 1 heavy chains. J Virol 71 2970-2979... 

Hughes EA, Hammond C, Cresswell P (1997) Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome. Proc Natl Acad Sci USA 94 1896-1901... 

Jones TR, Hanson LK, Sun L, Slater JS, Stenberg RM, Campbell AE (1995) Multiple independent loci within the human cytomegalovirus unique short region down-regulate expression of major histocompatibility complex class I heavy chains. J Virol 69 4830-4841 Jones TR, Sun L (1997) Human cytomegalovirus US2 destabilizes major histocompatibility complex class I heavy chains. J Virol 71 2970-2979... 

Machold RP, Wiertz EJ, Jones TR, Ploegh HL (1997) The HCMV gene products USl I and US2 differ in their ability to attack allelic forms of murine major histocompatibility complex (MHC) class I heavy chains. J Exp Med 185 363-366... 

Jones TR, Wiertz EJ, Sun L, Fish KN, Nelson JA, Ploegh HE (1996) Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains. Proc Natl Acad Sci USA 93 1 1327-11333... 

Rajagopalan, S., and Brenner, M.B. Calnexin Retains Unassembled Major Histocompatibility Complex Class I Free Heavy Chains in the Endoplasmic Reticulum J. Exp. Med. 1994 180, 407-412. 

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