Magnetic Resonance Imaging complexes

Future Applications. The use of gadolinium complexes as contrast agents in magnetic resonance imaging (mri) is growing (40). 

Sucralfate [54182-58-0] an aluminum salt of sucrose octasulfate, is used as an antacid and antiulcer medication (59). Bis- and tris-platinum complexes of sucrose show promise as antitumor agents (60). Sucrose monoesters are used in some pharmaceutical preparations (21). A sucrose polyester is under evaluation as a contrast agent for magnetic resonance imaging (mri) (61). Oral adrninistration of this substance opacifies the gastrointestinal tract and eliminates the need for purging prior to mri. 

Magnetic resonance imaging is a noninvasive structural technique for complex systems of molecules, such as people. In its simplest form, MRI portrays the concentration of protons in a sample. If the sample—which may be a living human body—is exposed to a uniform magnetic field in an NMR spectrometer and if we work at a resolution that does not show any chemical shifts or fine structure, then the protons... 

S. Sheppard, M. D. Mantle, A. J. Seder-man, M. L. Johns, L. F. Gladden 2003, (Magnetic resonance imaging study of complex fluid flow in porous media flow patterns and quantitative saturation profiling of amphiphilic fracturing fluid displacement in sandstone cores), Magn. Reson. Imag. 21, 365. 

Her present research interests are focused onto the design, synthesis of new lanthanide complexes as contrast agents for magnetic resonance imaging (MRI), as well as the development of a novel series of pH and p02 indicators for 111 NMR spectroscopic imaging ( II-MRSI). More recently, she has been involved in synthesis and evaluation of nanostructurated contrast agents. 

Toth E, Helm L, Merbach AE (2001) Relaxivity of Gadolinium(III) Complexes theory and mechanism. In Toth , Merbach AE (eds.) The chemistry of contrast agents in medical magnetic resonance imaging. Wiley, Chichester, pp. 45-119. 

The UC Davis M.I.N.D Institute (Medical Investigation of Neurodevelopment Disorders) explains the various advances in brain research like this, "Advances in imaging technology are enabling researchers to unravel the complexity of brain function. Functional magnetic resonance imaging (MRI) permits researchers to identify areas of the brain at work during specific activities and... 

Morphometric magnetic resonance imaging (MRI) studies provide further support for the concept of a subtle developmental brain anomaly. Szeszko et al. (1999) noted that OCD patients had reduced orbito-frontal and amygdala volumes bilaterally, and absence of the normal hemispheric asymmetry of the hippocampus-amygdala complex. Morphometric measurements of the basal ganglia also reveal decreased caudate size (Robinson et al., 1995 Jenike et al., 1996). 

Lanthanide complexes may also be employed as contrast agents in Magnetic Resonance Imaging (MRI), a non-invasive diagnostic tool... 

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