Mafenide acetate topical solution

Sodium sulfacetamide ophthalmic solution or ointment is effective in the treatment of bacterial conjunctivitis and as adjunctive therapy for trachoma. Another sulfonamide, mafenide acetate, is used topically but can be absorbed from burn sites. The drug and its primary metabolite inhibit carbonic anhydrase and can cause metabolic acidosis, a side effect that limits its usefulness. Silver sulfadiazine is a much less toxic topical sulfonamide and is preferred to mafenide for prevention of infection of burn wounds. 

Sulfamylon for 5% topical solution is provided in packets containing 50 g of sterile mafenide acetate to be reconstituted in 1000 mL of sterile water for irrigation or 0.9% sodium chloride irrigation. After mixing, the solution con-... 

Burned areas must be cleansed with sterile sahne solutions and an antiseptic such as povidone-iodine (Betadine). Broad-spectmm topical antibiotics are then appMed to burn areas. These include antibacterials such as mafenide acetate... 

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