Macrophages superoxide generation

As a consequence of the inhalation of mineral dusts, infiltration into the lung of inflammatory phagocytic cells, namely PMN and macrophages, occurs (Rola-Pleszczynski et al., 1984). Analysis of the cell populations of the rat pleural cavities after injection with asbestos and silica dust also showed both degranulation and reduction of the mast cell population (Edwards etal., 1984), and it is of interest to note that histamine augments the particle-stimulated generation of macrophage superoxide production (Diaz et al., 1979). 

It has been proposed that the capacity of antiinflammatory drugs to scavenge and inhibit ROM production is pertinent to their therapeutic effect (Hal-hwell et al., 1988). NSAIDs, namely indomethacin, inhibit superoxide generation by stimulated guinea-pig macrophages (Oyanagui, 1976) and the scavenging effects of PMN-derived ROMs by the sulphasalazine... 

Abo, A., Pick, E. (1991). Purification and characterisation of a third cytosolic component of the superoxide-generating NADPH oxidase of macrophages. J. Biol. Chem. 266, 23577-85. 

Rankin, J.A., Harris, P. and Ackerman, S.J. (1992). The efiects of eosinophil-granule major basic protein on lung-macrophage superoxide anion generation. J. Allergy Clin. Immunol. 89, 746-751. 

Pentoxifylhne (1 mM) stimulated the rate of rabbit alveolar macrophage spreading on glass covers-hps more than twofold (Wang et al. 1996). It reduced superoxide generation induced by phorbol-myristate-acetate by >50 %. Production of TNF-a induced by lipopolysaccharide was suppressed >85%. 

Rembish, S. J. Trush, M. A. Further evidence that lucigenin-derived chemiluminescence monitors mitochondrial superoxide generation in rat alveolar macrophages. Free Radical Biol. Med. 1994, 17, 117-126. 

Alveolar macrophage Respiratory bursts, superoxide generation Antibacterial activity... 

Hansen, K. and Mossman, B.T. (1987). Generation of superoxide (Oi ) from alveolar macrophages exposed to asbestiform and nonfibrous particles. Cancer Res. 47, 1681-1686. 

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