Macrophage Polarization

Maritovarii A, Sozzarii S, Locad M, Allavena P, Sica A (2002) Macrophage polar zadon Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immuriol 23 549-555. 

Sussman, E.M., Halpin, M.C., Muster, J., Moon, R.T., Ratner, B.D. Porous implants modulate healing and induce shifts in local macrophage polarization in the foreign body reaction. Ann. Biomed. Eng. 42, 1508-1516 (2014)... 

Sridharan, R., Cameron, A.R., Kelly, D.J., Kearney, C., O Brien, F.J. Biomaterial based modulation of macrophage polarization a review and suggested design principles. Materials Today (2015). doi 10.1016/j.mattod.2015.01.019... 

It is generally accepted that macrophage polarization toward the M2 phenotype displays positive healing outcomes in tissue repair, vascularization, and remodeling... 

Interestingly, it was demonstrated that biomaterials may modulate macrophage polarization and can actively direct the host response toward the implant, favoring tissue recovery [10] (Fig. 19.2). 

Figure 19.2 Microparticles implanted in the infarcted myocardium of a rat myocardial infarction model. The bioresorbable scaffold interacts with the host tissue, modulating macrophage polarization through the recruitment of antiinflammatory M2 macrophages and favoring tissue recovery. PLGA MP, poly(lactic-co-glycolic acid)-microparticle.

Meghari, S., Bermyer, C., Lepidi, H., Galland, F., Naquet, P., and Mege, J.L., 2007. Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection. European Journal of Immunology 37 24—32. 

Weigert, A. and Brune, B. (2008). Nitric oxide, apoptosis and macrophage polarization during tumor progression. Nitric Oxide 19, 95-102. 

Brown, B., Ratner, B., Goodman, S., Amar, S., Badylak, S., 2012. Macrophage polarization an opportunity for improved outcomes in biomaterials and regenerative medicine. Biomaterials 33 (15), 3792-3802. 

Hunziker W, Mellman I. Expression of macrophage-lymphocyte Fc receptors in Madin-Darby canine kidney cells polarity and transcytosis differ for isoforms with or without coated pit localization domains. / Cell Biol 1989 109(6 Pt 2) 3291-302. 

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