Macrophage depletion

Different dosage regimens were examined multiple doses of LC (15mg/kg) or LA (1.5mg/kg) at day —1 and day +6 were found to have same effect as one dose at day — 1. A single dose at day +6 had no effect. Treatment of LA, a single dose, at the time of injury required dose adjustment, and an increase of dose from 1.5mg/kg to 3mg/kg (76). LA administration at the time of injury caused transient suppression of monocytes, lasting less than one week, consistent with previous studies on monocyte and macrophage depletion after administration of LBP (52,96). 

Danenberg HD, Fishbein 1, Gao J, et al. Macrophage depletion by clodronate-containing liposomes reduces neointimal formation after balloon injury in rats and rabbits. Circulation 2002 106 599-605. 

Brosnan, C. F., Bronstein, M. B., and Bloom, B. R. (1981). The effects of macrophage depletion on the clinical and pathological expression of experimental allergic encephalomyelitis. J. Immunol. 126,614-620. 

Bottino, R., Fernandez, L. A., Ricordi, C., Lehmann, R., Tsan, M. F., Oliver, R. and Inverardi, L. (1998). Transplantation of allogeneic islets of Langer-hans in the rat liver Effects of macrophage depletion on graft survival and microenvironment activation. Diabetes 47, 316-323. 

Barrera P, Blom A, Van Lent PLEM, Van Bloois L, Storm G, Beijnen J, Van Rooijen N, Van De Putte LBA, Van Den Berg WB (2000) Synovial macrophage depletion with clodronate... 

Biewenga J, Van der Ende B, Krist LFG, Borst A, Ghufron M, Van Rooijen N (1995) Macrophage depletion and repopulation in the rat after intraperitoneal administration of Cl,MBP-liposomes depletion kinetics... 

Bergh A, Damber J-E, Van Rooijen N (1993) Liposome-mediated macrophage depletion an experimental approach to study the role of testicular macrophages. J Endocrinol 136 407... 

Tran EH, Hoekstra K, Van Rooijen N, Dijkstra CD, Owens T (1998) Immune invasion of the central nervous system parenchyma and experimental allergic encephalomyelitis, but not leukocyte extravasation from blood, are prevented in macrophage-depleted mice. J Immunol 161 3767... 

Gene expression and cellular proliferation are induced by the concomitant activation of protein kinase C and mobilization of Ca ". The activation of both of these pathways by phosphatidylinositol 4,5-bisphosphate hydrolysis, is necessary for DNA synthesis in macrophage-depleted human peripheral lymphocytes. However, the mechanisms regulating rapid cell proliferation are complex as demonstrated by their dependence on the combined presence of both activated protein kinase C and growth factors. 

Moores S, Talbot R, Evans N, et al. 1986. Macrophage depletion of mouse lung following inhalation of plutonium-239 dioxide. Radiat Res 105 387-404. 

Omer A, Keegan M, Czismadia E, De Vos P, Van Rooijen N, Bonner-Weir S, Weir GC. Macrophage depletion improves survival of porcine neonatal pancreatic cell clusters contained in alginate macrocapsules transplanted into rats. Xenotransplantation 2003 10 240-251. 

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