Macromolecules, controlled release

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The controlled release of macromolecules from non-erodible, hydrophobic polymeric matrices is modelled as a discrete diffusion process with the release of solute occuring through distinct pores in the polymer which are formed as solid particles of molecule dissolve. In order to formulate predictive models of the release behavior of these devices, quantitative information on the microgeometry of the system is required. We present a computer-based system for obtaining estimates of the system porosity, isotropy, particle shape, and particle size distribution from observations on two-dimensional sections from the polymer matrix. 

Schacht, E. "Polysaccharide Macromolecules as Drug Carriers" In "Controlled Release of Drugs from Polymer Particles and Macromolecules" Ilium, L. Davis, S.S. Eds. John Wright Bristol, in press. 

Bernkop-Schnurch A, Gockel NC (1997) Development and analysis of a polymer protecting from luminal enzymatic degradation caused by a-chymotrypsin. Drug Dev Ind Pharm 23 733-740 Bernkop-Schnurch A, Kast CE, Guggi D (2003) Permeation enhancing polymers in oral delivery of hydrophilic macromolecules thiomer / GSH systems. J Control Release. 2003 Dec 5 93(2) 95-103. 

Dendrimers Well-defined, nanosized, monodispersing macromolecules with hyperbranched structures Loading all kinds of active agents for good bioavailability, targeted delivery, and controlled release 23... 

Figure 5.31. Network (megamer) formation through the hydrolysis/crosslinMng of neighboring PAMAMOS dendrimer units. Hydrolysis of the C-O-Si bond may also be exploited for the controlled-release of entrained agents (e.g, cancer drugs, etc.). It should be noted that subsequent thermal annealing to remove the PAMAM cores results in a nanoporous network that has a dielectric constant (k) of ca. 1.5 - of extreme interest for next-generation IC interconnect applications. Reproduced with permission from Dvornic, P. R. Li, J. de Leuze-Jallouli, A. M. Reeves, S. D. Owen, M. J. Macromolecules, 2002, 35, 9323. Copyright 2002 American Chemical Society.

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