Macromolecular drug delivery systems, soluble

Table 15 Suggested Soluble Macromolecular Drug-Delivery Systems and Their Uses...

Soluble Macromolecular and Other Drug-Delivery Systems... 

Table 4 Considerations in the Pharmaceutical Development and Clinical Use of Both Soluble Macromolecular and Particulate Biotechnical and Site-Specific Drug Delivery Systems...

Einally, the enormous number of possible combinations of oppositely charged polymeric components that can be involved in interpolyelectrolyte complexation offers attractive perspectives for the preparation of water-soluble multicompartment nanosized macromolecular co-assemblies with desired properties. We believe that such novel IPECs are very promising and will be in demand for their future applications in nanomedicine (e.g., gene and drug delivery, and diagnostic systems), biotechnology, and nanotechnology as nanocontainers, nanoreactors, and molecular templates for nanoelectronic devices. 

The dissolution of the polymer component of an erodible implant system for drug delivery may be achieved in two ways. For the Type A polymer matrix, the soluble hydrolytic products remain macromolecular. An example of such a polymer is poly(vinyl acetate) which can be de-acetylated to give the water-soluble poly(vinyl alcohol). In the Type B scheme, the matrix is degraded into low molecular weight fragments like in the ester hydrolysis of polycaprolactone. Previous work in this... 

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