Macfarlane Smith

MacDermid hic., 237 Macfarlan Smith Pic, 211 MAGLITE , magnesium oxides, 84 Magma Copper Corporation, 207, 237 MAGNACIDE H , acrolein, 84 Magnesita SA, 146... 

Opium contains a complex mixture of almost twenty-five alkaloids. The principle alkaloid in the mixture, and the one responsible for analgesic activity, is morphine, named after the Roman god of sleep—Morpheus. Although pure morphine was isolated in 1803, it was not until 1833 that chemists at Macfarlane Co. (now Macfarlane-Smith) in Edinburgh were able to isolate and purify it on a commercial scale. Although the functional groups on morphine had been identified by 1881, it took many more years to establish the structure of morphine and it was not until 1925 that Sir Robert Robinson solved the puzzle. Another twenty-seven years were to pass before a full synthesis of morphine was achieved in 1952. 

The drugs used are listed in Table I. Atropine sulphate was purchased from B.D.H. Ltd and hyoscine hydrobromide from Macfarlan Smith Ltd. All the other drugs were prepared in these laboratories and were used as the hydrochlorides. Doses were given in mg/kg as indicated above but for calculation of correlation coefficients these were converted into /xmoles/kg. 

The process by which denatonium benzoate is made is a proprietary secret of the Macfarlan Smith corporation. A proprietary secret is a method of making a product for which... 

ROBERTSON, G.W., GRIFFITHS, D.W., MACFARLANE SMITH, D. BUTCHER, R.D., The application of thermal desorption-gas chromatography-mass spectrometry to the analyses of flower volatiles from five varieties of oilseed rape (Brassica napus spp. oleifera). Phytochem. Anal, 1993,4, 152-157. 

GlaxoSmithKline, Johnson and Johnson, Johnson Matthey and Mayne produce opiates in Tasmania and Australia, Sanofi Aventis in France, Shionogi in Japan and Macfarlan Smith (now part of Johnson Matthey) in Britain. Mallinckrodt, Noramco, Abbott Laboratories and Purdue Pharma import these from Turkey and india to the USA. 

The world s oldest pharmaceutical companies, such as MacFarlan Smith Ltd. in Edinburgh or Merck at Darmstadt, were founded on the alkaloid business. 

McEwan, M., MacFarlane-Smith, W.H., Identification of volatile organic compounds emitted in the field... 

McEwan, M., MacFarlane-Smith, W.H., Identification of volatile organic compounds emitted in the field by oilseed rape (Brassica napus ssp. Oleifera) over the growing season. Clin. Exp. Allergy, 28,332-338, 1998. 

Griffith D.W., Macfarlane-Smith W.H., Boag B. The effect of cultivar, sample date and grazing on the concentration of S-methylcysteine sulfoxide in oilseed and forage rapes (Brassica napus). Journal ofthe Science of Food and Agriculture, 64 283-288 (1994). 

Griffiths, D.W., Birch, A.N.E. and Macfarlane-Smith, W.H. (1994) Induced changes in the indole glucosinolate content of oilseed rape and forage rape (Brassica napus) plants in response to either turnip root fly or artificial root damage. J. Scl Food Agric., 65,171-178. 

---