Lysergic acid structure

Common Name d-Lysergic acid dl-hydroxybutylamide-2 methylergometrin maleate Structural Formula ... 

LUMO, see Lowest unoccupied molecular orbital Lyase, 1041-1042 Lycopene, structure of, 483 Lysergic acid diethylamide, structure of, 963... 

The compounds 12,14 and 15 can be prepared from parent lysergic acid amides by bromination with NBS or PHT, but not the compounds of the type 12. The latter structure is very sensitive and under these circumstances only degradation products were obtained. Besides it was necessary to use much milder reagent, e.g. bromine bonded onto polymeric matrix with polyvinylpyrrolidone or polyvinylpyridine structure (29) ... 

Baker, R. W., Chothia, C., Pauling, P., and Weber, FI. P. (1973) Molecular structures of hallucinogenic substances Lysergic acid diethylamide, psilocybin, and 2,4,5-trimethoxyam-phetamine. Mol. Pharmacol., 9 23-32. 

Seven groups of these drugs can be separated based on their various chemical f structures (a) lysergic acid derivatives, of which lysergide (LSD) is the prototype (b) phenylethylamine derivatives, of which 3,4,5-trihydroxyphenylethylamine (mescaline) is the prototype (c) indolealkylamines, such as 4-phosphorodi-methyltryptamine (psilocybin) (d) other indolic derivatives, such as the harmine... 

The most potent compound in this series, if not one of the most potent drugs or toxins known, is LSD. A number of clinical comparisons have been made between LSD and closely related lysergic acid derivatives. It appears that alterations in the basic structure of LSD may or may not materially change the quality of the clinical effects but generally tend to reduce potency. 

Woodward then moved across town in Cambridge to devote a year of postgraduate study at Harvard University. At the end of that year, he accepted an appointment to the Harvard chemistry faculty, a post he held for most of the rest of his life. One of his great interests at Harvard was the synthesis of large, complex molecules, the first of which was quinine in 1944. He followed that work with the elucidation of other molecular structures and the development of synthetic methods for each. Included among these molecules were penicillin (1945), patulin (1948), cholesterol and cortisone (1951), oxytetracycline (1952), strychnine (1954), lysergic acid (1954), reserpine (1956), chlorophyll (1960), colchicine (1963), cephalosporin C (1965), and vitamin (1971). 

LSD (4.126) is a rather structure-specific compound. Only the (+)-isomer is active, and alkylamides other than the diethyl derivative, including some cyclic analogs (the pyrro-lidide and morpholide analogs), have very low activity. Lysergic acid does contain the... 

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