Lysergic acid diethylamide, structure

LUMO, see Lowest unoccupied molecular orbital Lyase, 1041-1042 Lycopene, structure of, 483 Lysergic acid diethylamide, structure of, 963... 

Baker, R. W., Chothia, C., Pauling, P., and Weber, FI. P. (1973) Molecular structures of hallucinogenic substances Lysergic acid diethylamide, psilocybin, and 2,4,5-trimethoxyam-phetamine. Mol. Pharmacol., 9 23-32. 

Most ergot alkaloids stimulate the sympathetic structures-of the mesencephalon and diencephalon, particularly the hypothalamus, leading to a syndrome of excitation with mydriasis, hyperglycemia, tachycardia, etc. This syndrome may be closely related to the psychotomimetic effects of certain alkaloid derivatives, e.g., lysergic acid diethylamide. 

Lysergic acid a tetracyclic indole derivative, M, 368.32. The D-form, m.p. 240 °C (d.), [a]g -i-40° (c = 0.5, pyridine), is one of the Ergot alkaloids (see). Change of configuration at C8 produces biologically inactive isolysergic acid, L. is a close structural relative of LSD (see Lysergic acid diethylamide). 

Ishii, H., Niwaguchi, T., Nakahara, Y. and Hayashi, M. (1980) Studies on lysergic acid diethylamide and related compounds. Part 8. Structural identification of new matabolites of lysergic acid diethylamide obtained by microbial transformation using Streptomyces roseochromogenes. J. Chem. Soc. Perkin Trans. 1, 902—905. 

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