Lymphoreticular

An increased ratio of T suppressor cells to T helper cells was seen in mice given 2.5 and 5.0 mg/kg/day of methyl parathion for 15 days the spleen to body weight ratio was increased at 5 mg/kg/day (Tian et al. 1997). No other immunological or lymphoreticular end points were measured. 

Some animal studies indicate that dietary exposure to methyl parathion causes decreased humoral and cellular responses (Shtenberg and Dzhunusova 1968 Street and Sharma 1975). A more recent, well-designed animal study that included a battery of immuno/lymphoreticular end points showed few effects at the nonneurotoxic doses tested (Crittenden et al. 1998). No adequate studies are available in humans to assess the immunotoxic potential of methyl parathion. Therefore, studies measuring specific immunologic parameters in occupationally exposed populations are needed to provide useful information. Further studies are also needed to investigate the mechanism for methyl parathion-induced immunotoxicity since this information would help to identify special populations at risk for such effects. 

Lymphoreticular Effects—Represent morphological effects involving lymphatic tissues such as the lymph nodes, spleen, and thymus. 

Immunological and Lymphoreticular Effects. No studies were located regarding immunological... 

In patients with ataxia-telangiectasia, an autosomal recessive disease in humans resulting in the development of cerebellar ataxia and lymphoreticular neoplasms, there appears to exist an increased sensitivity to damage by x-ray. Patients with Fanconi s anemia, an autosomal recessive anemia characterized also by an increased frequency of cancer and by chromosomal instability, probably have defective repair of cross-linking damage. 

The cells that make up the immune system are distributed throughout the body but are found mainly in the lymphoreticular organs, which may be divided into the primary lymphoid organs, i.e. the thymus and bone marrow, and the secondary or peripheral... 

MATSUMOTO T, YAMADA H (2000) Orally administered Kampo (lapanese herbal) medicine, Juzen-Taiho-To modulates cytokine secretion in gut associated lymphoreticular tissues in mice. Phytomedicine. 6 425-30. 

Immunological and Lymphoreticular Effects. Depressed white blood cell counts have been observed in humans and animals exhibiting relatively high body burdens of241 Am following accidental or... 

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