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Lymphokines, recovery

One component of the age-ielated decline in immune function is decreased production of the lymphokine that promotes the growth of T-ceUs, interleukin 2 (IL-2). Administration of recombinant-derived IL-2, both in vitro and in vivo, appears to restore certain immune functions in aged mice. Recovery of T-regulatory effects on B-ceU differentiation has been reported in human cells from elderly patients treated with IL-1 and/or IL-2 (42). Similar effects have been observed in the presence of the pentapeptide thymopentin [69558-55-0] (Arg Lys Asp Val Tyr), a weU-known IL-2 inducer. Recombinant IL-2 adrninistered to aged mice for three weeks has been shown to correct the T-ceU functional deficiency associated with antigen-specific immunoglobulin production by certain lymphoid tissue (43). [Pg.431]

Several ultrafiltration (UF) membrane systems have been evaluated for large-scale (20-300 liter) recovery of lymphokines, virus and monoclonal antibodies from eukaryotic cells and for concentration of a microbially produced cytotoxic chromoprotein, largomycin F-ll. [Pg.29]

Recovery of Lymphokines. A number of pilot-scale production runs were performed using a murine cell line which is a constitutive producer of a lymphokine, interleukin-3. This material is approximately 28,000 daltons, and was produced in low protein medium,... [Pg.45]

In mice with immune suppression induced by cyclophosphamide, intraperitoneal administration of 2.5, 25, or 250 mg/kg of reishi polysaccharides daily for 7 days enhanced the function of immunological effector cells. The 2.5 mg/kg dose accelerated recovery of bone marrow cells, red blood cells, white blood cells, splenic natural killer cells, and natural killer T cells, and enhanced T and B cell proliferation responses, cytotoxic T lymphocyte activity, and NK cell and lymphokine activated killer cell activity (Zhu etal. 2007). [Pg.389]


See other pages where Lymphokines, recovery is mentioned: [Pg.63]    [Pg.50]    [Pg.334]   
See also in sourсe #XX -- [ Pg.37 , Pg.39 , Pg.40 , Pg.41 ]




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Lymphokines

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