Lymphocytic pleocytosis

Electrophysiologic studies usually show axonal neuropathy, but in 15%, it is demyelinating (Moulignier et al. 1997). CSF is remarkable for a mild nonspecific lymphocytic pleocytosis, but with markedly raised protein up to 2 g/L (Brew 2003). Nerve biopsy shows marked angiocentric CD8 infiltrates without mural necrosis... 

Lymphocytic oligocytosis or lymphocytic pleocytosis, usually to a mild degree—simultaneously a plasmocytic response occurs. 

Serous neuroinfections—the appearance of lymphocytic pleocytosis or lymphocytic oligocytosis is present. In this case, the element count is higher than 100/3 /U.1 (35//U.1) and the probability of the diagnosis of multiple sclerosis is very low. 

Lymphocytic Pleocytosis. Lymphocytic pleocytosis is indicated by a prevailing representation of lymphocytic line elements and a high representation of activated forms which, in the event of a chronic course of the lesion, evolve (in B-system elements) into plasma cells. This picture is quite typically associated... 

Lymphocytic pleocytosis Activated lymphocytes Serous neuroinfections... 

With chronic, persistent pneumonia, C. immitis often can be cultured from the sputum for a period of several years. Chest radiographs usually demonstrate apical fibronodular lesions or slowly progressive cavitation. With CNS infection, analysis of the CSF generally reveals a lymphocytic pleocytosis with elevated protein and a decreased glucose concentration. Although serum usually is positive for coccidioidal CF antibodies, the coccidioidal skin test is often negative. 

In the first 3 days of illness, leukopenia and elevated serum glutamic-oxaloacetic transaminase (SGOT) are common. For those with CNS involvement, a lymphocytic pleocytosis of up to 500 cells per microliter will be observed in the CSF. The CSF pleocytosis may acutely be polymorphonuclear but soon becomes predominantly lymphocytic. 

Examination of cerebrospinal fluid (CSF) in patients with cryptococcal meningitis generally reveals an elevated opening pressure, CSF pleocytosis (usually lymphocytes), leukocytosis, a decreased CSF glucose, an elevated CSF protein, and a positive cryptococcal antigen. 

Laboratory examination of the CSF usually reveals a pleocytosis with 100 to 1000 WBCs/mm , which are primarily lymphocytic however, 20% to 75% of patients with viral encephalitis may have a predominance of polymorphonuclear cells on initial examination of the CSF, especially in enteroviral meningitis. On repeat lumbar puncture, 90% of patients presenting initially with a predominance of neutrophils experience a shift to a predominance of mononuclear cells. Other laboratory findings include normal to mildly elevated protein concentrations and normal or mildly reduced glucose concentrations (see Table 105-1). 

---