Lymphocyte activation, regulation

Bachmaier, K., et al., Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature, 2000,... 

Bachmaier, K., C. Krawczyk, I. Kozieradzki, Y. Y. Kong, T. Sasaki, A. Oliveira-dos-Santos, S. Mariathasan, D. Bouchard, A. Wakeham, A. Itie, J. Le, P. S. Ohashi, I. Sarosi, H. Nishina, S. Lipkowitz, and J. M. Penninger. Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b. Nature. 403 211-6.2000. 

Hermiston ML et al Reciprocal regulation of lymphocyte activation by tyrosine kinases and phosphatases. J Clin Invest 2002 109 9. [PMID 11781344]... 

STAT4 a member of the STAT family of branscription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that h anslocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL-12 in lymphocytes, and regulating the differentiation of T helper cells. 

N. A. Gomes, J. O. Previato, B. Zingales, L. Mendonga-Previato, and G. A. DosReis, Down-regulation of T lymphocyte activation in vitro and in vivo induced by glycoinositolphospholipids from Trypanosoma cruzi. Assignment of the T cell-suppressive determinant to the ceramide domain, J. Immunol., 156 (1996) 628-635. 

Calcineurin (protein phosphatase 2B) is a Ser/Thr phosphatase that is controlled by cellular calcium and regulates a large number of biological responses including lymphocyte activation, neuronal and muscle development, and the development of vertebrate heart valves. 

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