Lupron Depot endometriosis

B. Indications and use Lupron Injection, Lupron Depot, Lupron Depot-3 Month, and Lupron Depot-4 Month are indicated in the palliative treatment of advanced prostate cancer. These products offer an alternative treatment when orchiectomy or estrogen administration is either not indicated or unacceptable to the patient. Lupron Injection Pediatric and Lupron Depot-PED are indicated in the treatment of children with central precocious puberty. Lupron Depot and Lupron Depot-3 Month are indicated for the management of endometriosis, including pain relief and reduction of endometriotic lesions. 

Recommended dosage and monitoring requirements According to Micromedex, the effective doses of Lupron in prostate cancer are 1 mg subcutaneously daily, or in the depot formulation 7.5 mg intramuscularly (IM) monthly, 11.25 mg every 3 months, or 30 mg every 4 months. Lupron Depot-3 month 22.5 mg is used in the treatment of advanced prostate cancer. In endometriosis, the effective dose is 3.75mg depot IM monthly or 11.25mg every 3 months for 6 months. In central precocious puberty, the recommended starting dose of Lupron Injection Pediatric is 50pg/kg... 

Based on these limitations, only a limited number of drug delivery systems based on biodegradable polymers have so far been successfully commercialized. One example is Lupron Depot one-month injectable microspheres of PLGA containing leuprorelin acetate (LH-RH agonist) for the treatment of endometriosis and prostatic cancer [31,32]. 

The Lupron Depot microspheres are indicated for the treatment of male patients with prostate cancer and female patients suffering from endometriosis and anemia due to fibroids. Each depot formulation is... 

Lupron Depot Leuprolide PLGA or PLA TAP Prostate cancer, endometriosis... 

Dlugi, A.M. Miller, J.D. Knittle, J. Lupron depot (leuprohde acetate for depot suspension) in the treatment of endometriosis a randomized, placebo-controlled, doubleblind study. Lupron study group. Fertil. Steril. 1990, 54 (3), 419 27. 

Leuprolide acetate, a synthetic nonapeptide, is prescribed for the treatment of metastatic prostate cancer and endometriosis. Leuprolide acetate is presented in a number of injectable dosage forms including Lupron sterile solution for subcutaneous administration (1 and 5 mg mL 1) and Lupron depot controlled release formulation for intramuscular injection (3.75 and 7.5 mg). Zheng and Fulu [106] have evaluated the in vivo effect of leuprolide loaded micro emulsions on the genital organs of the male and female rats. In the preliminary pharmacokinetic studies, oral microemulsions of leuprolide administration resulted in 10-fold higher plasma levels of leuprolide as compared to that of saline solution (Fig. 9.4). 

The GnRH agonists also are used to suppress steroid-responsive conditions such as endometriosis, uterine leiomyomas, and acute intermittent porphyria. Nafarelin (SYNAREL) is administered by nasal spray for endometriosis. Depot preparations of goserelin (ZOLADEX), leuprolide (LUPRON DEPOT, elegard) Or triptorelin (trelstar la), which can be administered subcutaneously or intramuscularly monthly or every 3 months, can be used in these settings and may be particularly useful for pharmacological castration in disorders such as paraphilia, for which strict patient compliance is problematic. 

Leuprolide acetate/poly(DL-lactide-co-glycolide) Lupron Depot , Takeda Chemical Industries Endometriosis... 

Hornstein MD, Surrey ES, Weisberg GW, Casino LA. Leuprolide acetate depot and hormonal add-back in endometriosis A 12-month study. Lupron Add-Back Study Group. Obstet Gynecol 1998 91 16-24. 

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