Lung retention and mouth absorption of several cigarette mainstream smoke components

Lung Retention and Mouth Absorption of Several Cigarette Mainstream Smoke Components 

Smoke Component Delivery Retention % Exhaled Absorbed in Mouth % Exhaled 

The data presented by Dalhamn et al. (892, 893) on lung retention of MSS components were similar to data reported earlier by Laskowski (2267) and to data on Inng retention and mouth absorption of ciliastats by Rodgman et al. (3306). The various sets of data are summarized in Table III-IO. Each set of data indicates that exhaled MSS is substantially different quantitatively from the inhaled MSS. 

If cigarette MSS is month inhaled and held for any length of time (a few seconds) in the month prior to being drawn into the lungs, some of the MSS water-soluble vapor-phase components are scrnbbed from the smoke stream and reach the ciliated areas at mnch rednced concentrations. This is also true to a lesser degree for water-soluble components of the particulate phase (see Tables III-8, III-9, and III-IO). 

these mechanisms— scrubbing and resorption — effective in snbstantially diminishing the amounts of MSS water-soluble in vitro ciliastats that reach the lung dnring active smoking will be operative during ETS inhalation, whether oral or nasal, and diminish the amounts of the same and similar ETS components that reach the lung. This diminution in amounts will be particnlarly pertinent in the case of the smoke components formaldehyde, acetaldehyde, crotonaldehyde. 

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