Lung deposition breathing parameters

Most lung deposition models are based on the influence of particle size on aerosol deposition. Breathing parameters, such as breathing frequency and tidal volume, play a key role in lung deposition [15]. Table 2 shows the breathing parameters for healthy male volunteers subjected to various levels of exercise on a bicycle ergometer [16], There are known differences in these parameters based on gender, age, and disease... 

Comparative Toxicokinetics. Available data Ifom ehronic rat inhalation bioassays show similar asbestos-induced respiratory effects to those in humans assoeiated with oeeupational exposure to asbestos (pulmonary fibrosis, lung cancer, and pleural mesothelioma), but the use of the rat data to predict human health risks from exposure to airborne asbestos has a number of areas of uneertainty, including those associated with interspecies differences in lifespan, airway morphometry, and breathing patterns. The development of rat and human lung retention models that incorporate species differences in anatomical and physiological parameters influencing deposition and clearance of asbestos fibers may decrease the... 

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