Lubricants sodium hyaluronate

The beneficial effects of sodimn hyaluronate follow from its viscoelastic properties, which lubricate as well as protect the ocular surface. A study foimd a 0.2% solution of sodium hyaluronate had a significantly longer ocular residence time than did 0.3% HPMC or 1.4% PVA. Most patients achieve control of symptoms with topical instillation up to four times daily. Subjective relief of symptoms such as burning and grittiness usually occurs immediately after drug instillation, and these effects can last 60 minutes or longer. 

Lubricant (hair and skin) Mink oil, sodium hyaluronate Coconut oil, lanolin, olive oil, petrolatum... 

Many drugs that have an anti-inflammatory action may also have other mechanisms of action. Corticosteroids are one of the most commonly administered classes of intraarticular medication in equine medicine. Hyaluronan (sodium hyaluronate, HA) is a natural component of the joint and its intraarticular use has anti-inflammatory actions and may have lubricating effects. Similarly dimethyl sulfoxide is used for both its anti-inflammatory and its antimicrobial actions. 

Sodium hyaluronate, or HA, is a biocompatible polysaccharide that is encountered in medicine and the cosmetics industry. Its macroscopic properties are highly sensitive to its hydration level, which is the reason why it has been the object of many studies. When in its dried state, or scarcely hydrated, it is stiff. In this state it may act as a skin-stiffening agent, smoothing wrinkles for instance. When highly hydrated, it acts as a lubricant that is found in synovial fluid. The elucidation of its hydration mechanism has shown us the role of the developing H-bond network in the change of its properties and, at the same time, the power and sensitivity of IR spectrometry to observe water molecules in macromolecules. 

Mori S, Naito M, Moriyama S. Highly viscous sodium hyaluronate and joint lubrication. Int Orthop 2002 26 116-121. 

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