LSD lysergic acid

LS coupling Russell-Saunders coupling. LSD Lysergic acid diethylamide. An hallucinogen. 

LSD (lysergic acid diethylamide) Acid, blotter, blue devils, California sunshine, haze, microdot(s), mickeys, Mr. Natural, paper acid, purple haze, sunshine, wedges, window pane(s)... 

LSD lysergic acid diethylamide inherited Leigh s syndrome... 

DA, dopamine 5-HT, serotonin LSD, lysergic acid diethylamide, MAOI, monoamine oxidase inhibitor, NE, norepinephrine PCP,... 

EFA essential fatty acid LSD lysergic acid diethylamide... 

LSD (lysergic acid diethylamide) Street Names Acid> mellow yellow... 

LSD lysergic acid diethylamide LVD left ventricular dysfunction... 

Hallucinogen-like activity of these compounds as potential bioisosteres of T,T-dimethyltryptamine was evaluated in the two-lever drug discrimination paradigm using LSD- and DOI-trained rats (LSD = lysergic acid diethylamide DOI = 2,5-dimethoxy-4-iodoamphetamine). 

In 1954, i.e. about 2 years after the discovery of chlorpromazine in Europe, two American biochemists (Woolley and Shaw) published the hypothesis that schizophrenia and similar psychoses could be based on a disturbance of serotoninergic neurotransmission in the brain. This hypothesis was supported by some facts that had become known shortly beforehand the spectacular psychotropic actions of LSD (lysergic acid diethylamide), which can trigger disturbances in perception, thought and feelings as well as hallucinations in healthy subjects (Stoll, 1947) and the serotonin-antagonistic effects of LSD, i.e. its ability to block the actions of serotonin in various pharmacological tests. 

LSD (Lysergic acid diethylamide) Psychedelic drug and hallucinogen used as incapacitating agent. 

ACPD, fra/7S-l-amino-cyclopentyl-l,3-dicarboxylate AMPA, DL-tt-amino-3-hydroxy-5-methylisoxazole-4-propionate cAMP, cyclic adenosine monophosphate CQNX, 6-cyano-7-nitroquinoxaline-2,3-dione DAG, diacylglycerol IP3, inositol trisphosphate LSD, lysergic acid diethylamide MCPG, a-methyl-4-carboxyphenylglycine. 

HTxR, serotonin receptor CB1R, cannabinoid-1 DAT, dopamine transporter GABA, y-aminobutyric acid Kir3 channels, G protein-coupled inwardly rectifying potassium channels LSD, lysergic acid diethylamide i -OR, H-opioid receptor nAChR, nicotinic acetylcholine receptor NET, norepinephrine transporter NMDAR, N -methyl-D-aspartate receptor SERT, serotonin transporter VMAT, vesicular monoamine transporter indicates data not available. 

LSD metabolism was investigated using MS-MS. Metabolites were determined using MS-MS. The main metabolite was 2-oxo-3-hydroxy-LSD (O-H-LSD) present in urine at concentrations of 2.5 and 6.6 pg/L, respectively, for case 1 and 2, but it was not detected at all in plasma. Nor-LSD was also found in urine at 0.15 and 0.01 pg/L levels. Nor-iso-LSD, lysergic acid ethylamide (LAE),... 

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