Drug discrimination paradigm

TABLE 4. ED q values for substitution in LSD-trained or MDMA-trained rats, in the drug discrimination paradigm... 

COMMENT/QUESTION 1 was very intrigued by your substitution data from the drug discrimination paradigm. But my question is not unlike Lou Seiden s. For with substances that are characterized by tremendously qualitatively different effects, biphasic in nature, and in many functional... 

The relevance of PCP receptors is supported by reports that the ability of PCP-like drugs to produce PCP-like stimulus in drug discrimination paradigms (Shannon 1981 Holtzman 1980 Brad and Balster 1981), produce vasoconstriction (Altura et al. 1983) and produce ataxia (Vincent et al. 1979 Vignon et al. 1982 Vaupel et al. 1984) correlates well with their ability to bind to PCP receptors. 

Animal drug discrimination paradigms show cross-tolerance between cathinone, cathine, and amphetamine (Schechter 1990). S(-i-)methcathi-... 

Subjective effects The subjective effects of DMT are very much like those of the other monoamine hallucinogens. Animal drug discrimination paradigms indicate that DMT and related compounds produce similar effects to LSD (Heisley et al. 1998). However, j3-carbolines do not substitute well for LSD in these paradigms. Maximal substitution occurs with harmane only at intermediate levels. Some have reported that unlike... 

Hallucinogen-like activity of these compounds as potential bioisosteres of T,T-dimethyltryptamine was evaluated in the two-lever drug discrimination paradigm using LSD- and DOI-trained rats (LSD = lysergic acid diethylamide DOI = 2,5-dimethoxy-4-iodoamphetamine). 

In contrast, ibogaine substituted as an interoceptive cue in mice trained to recognize MK-801 (dizocilpine) (119), but not to [(+)-HA-966] (a low-efficacy partial agonist of the glycine site at the NMDA receptor) (130) in a T-maze drug discrimination paradigm. 

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