Low Molecular Weight Organogelators

Brosse, N., D. Barth, and B. Jamart-Gregoire, A family of strong low-molecular-weight organogelators based on aminoacid derivatives. Tetrahedron Letters, 2004.45(52) 9521-9524. 

Gelation of low molecular weight compounds was discovered by chance. About one hundred types of low molecular weight organogelators have been reported. Historical or typical organogelators, except those discovered by the present author are summarized in Scheme 2.14 l,3 2,4-dibenzylidene-D-sorbitol (49), 12-(5)-... 

The bisurea-amino acid conjugates 166-168, a new type of low molecular weight organogelators, have been prepared by Hamilton [116]. The compounds were obtained by the reaction of xylylene-l,4-bisisocyanate and tert-butyl esters of L-Ala, L-Phe, and L-Val (Scheme 24). 

In recent years, many groups have employed the click reaction in the supramolecular environment of organogels and hydrogels. One such example is in the stabilization of low molecular weight organogelators 14 and 15 based on the undecynylamide of trans-l, 2-diaminocyclohexane... 

The low molecular-weight organogel has two fascinating properties. One is a physical gel property, which is attributed to the noncovalent interactions to maintain the organogel supramolecular structure. The physical organogel is responsive to external stimuli such as thermo-, photo-, chemo-, metal-, proton-, mechano-, by which the aggregate structure is stabihzed or desta-... 

Rizkov et al. ° used L-and D- 3-amino alcohols for the enantioseparation of, among others, dansylated (Dns) AAs by CZE in a low-molecular-weight organogel (LMOG)-filled capillary. This LMOG is a fibrillar gel of trans-(15,2S)-l,2-bis-(dodecylamido) cyclohexane in MeOH. Bare fused-silica capillaries with an i.d. of 100 fim and a total length of 60.0 cm (52.0 cm effective length) were used. The BGE contained 10-mM 3-amino alcohol and 5-mM cupric acetate monohydrate in MeOH with pH 5. The selector copper-valinol (2 1) performed best compared... 

Rizkov D, Mizrahi S, Cohen S, Lev O. (i-Amino alcohol selectors for enantioselective separation of amino acids by ligand-exchange capillary zone electrophoresis in a low molecular weight organogel. Electrophoresis 2010 31 3921-3927. 

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