Long-term nitrate

Andreassi MG, Picano E, Del Ry S, Botto N, Colombo MG, Giannessi D, Lubrano V, Vassalle C, Biagini A. Chronic long-term nitrate therapy possible cytogenetic effect in humans Mutagenesis 2001 16(6) 517-21. 

Polythene bottles are not suitable for long-term storage of plutonium nitrate solutions as radiation-induced stress cracks appeared in the bases of several 10 1 bottles during 6 months storage. Short-term storage and improved venting are recommended. 

Figure 6.6. Long-term changes of Uts of metals in a loessial soil from Israel. The soil received metal nitrates under field the capacity moisture regime (after Han and Banin, 1999. Reprinted from Water Air Soil Pollut, 114, Han F.X and Banin A., Long-term transformations and redistribution of potentially toxic heavy metals in arid-zone soils. II Incubation under field capacity conditions, p 245, Copyright (1999), with permission from Springer Science and Business Media)...

In other work, C87-3754has been compared with SIN-1, the equivalent metabolite from molsidomine, and from the organic nitrate class, isosorbide-5-mononitrate (IS-5-MN) [146]. In this latter study, which involved long term oral administration in a dog model, IS-5-MN showed tolerance whilst the sydnonimines showed no self- or cross-tolerance. Elsewhere, tolerance studies in dogs by oral or continuous infusion of C87-3754 have shown benefits in the treatment of a failing heart, without tolerance [147] and with better results than those observed by nitroglycerin [148]. 

Long-term field trials in England have shown that N efficiency of cattle slurry applications declined once the application rate exceeded pasture plant requirements [7], The cattle slurry was reported to be 90% as efficient as ammonium nitrate fertiliser when applied at 300kg N/ha compared with 63% efficient at 600kg N/ha and that the efficiency varied with season of application, being most effective in spring. 

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