Long-term facilitation

Si, K., Giustetto, M., Etkin, A. et al. A neuronal isoform of CPEB regulates local protein synthesis and stabilizes synapse-specific long-term facilitation in aplysia. Cell 115 893-904, 2003. 

Moreover, an UCH (Ap-uch) that interacts with the proteasome was found to be induced by 5-HT, the neurotransmitter that induced long-term facilitation. Ap-uch was found to be critical for the induction of longterm facilitation. Subsequently, Chain et al showed that at sensory-motor neuron synapses, injection of lactacystin, a specific proteasome inhibitor blocked induction of long-term facilitation. Since R subunit inhibits the activity of C subunits of PKA, the results were interpreted to suggest that the ubiquitin-proteasome pathway operates to remove inhibitory constraints on the formation of long-term memory. This has been... 

Martin KC, Casadio A, Zhu HEY, et al Synapse specific long term facilitation of Aplysia sensory to motor synazases a function for local protein synthesis in memory storage. Cell 91 927-938, 1997... 

Hoffman MS, Mitchell GS. Spinal 5-HT7 receptors and protein kinase A constrain intermittent hypoxia-induced phrenic long-term facilitation. Neuroscience 2013 250 632-43. 

Peng Y Kline DD, Hamadani A, Prahhakar NR. Induction of long term facilitation in the carotid body activity by intermittent h poxia. FASEB J 2001 15 A153. 

Bach KB, Mitchell GS. Hypoxia-induced long-term facilitation of respiratory activity is serotonin dependent. Respir Physiol 1996 104 251-260. 

The improvement of the quality of a design is seen as the primary need of industry, but to facilitate this we need appropriate methods for predicting quality and evaluating the long-term quality of an engineer s design (Morup, 1993 Russell and Taylor, 1995 Shah, 1998 Taguchi et al., 1989). However, there is relatively little work... 

The pharmacoeconomics of the anxiety disorders has received litde attention. In the past drug costs were largely incurred by use of benzodiazepines, most of which are available in generic forms and are cheap. They are effective and acceptable in the short term. Long-term use is associated with the risk of physical dependence, with an adverse risk—benefit ratio and high cost terms to facilitate withdrawal. There is now a trend towards the use of antidepressants in the anxiety disorders. Clinical experience has been followed by formal trial evaluation. 

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