Long-term effects tumorigenicity

Somewhat in contrast, there are considerable data concerning the relatively long-term effects of exposure to toxic materials, where there are irritation, tumorigenic, reproductive, or mutation consequences (National Institute for Occupational Safety and Health, Registry of Toxic Effects of Chemical Substances, 1983). In the... 

In recent years a growing concern has developed with regard to long-term exposure to hypolipidemic agents, certain herbicides and industrial plasticizers (DEHP and DEHA) and the possible effect on human health. These concerns have basically centered on the tumorigenic property of peroxisome proliferators. There is a large body of evidence to indicate an... 

Toxicology LD50 (oral, rat) 373 mg/kg, (subcut., mouse) 135 mg/kg poison by ing. and subcut. routes harmful if swallowed corrosive causes burns severe skin and eye irritant possible sensitizer possible carcinogen experimental tumorigen human mutagenic data TSCA listed Environmental Very toxic to aquatic organisms may cause long-term adverse effects in the aquatic environment avoid release to the environment... 

Dilulio, N. A., Yamakami, K., Washington, S., and Bhavanandan, V. P., 1994, Effect of long-term culture of a human laryngeal carcinoma cell line on epitectin production and tumorigenicity in athymic mice, Glycosylation Dis. 1 21-30. 

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