Lomotil - Diphenoxylate hydrochloride

Diphenoxylate Hydrochloride. l-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-4-piperidinecarboxyhc acidmonohydrochlorhydrate [3810-80-8] (Lomotil) (13) is a white, odorless, crystalline powder that melts at 220—226°C. It is soluble ia methanol, spariagly soluble ia ethanol and acetone, slightly soluble ia water and isopropyl alcohol, freely soluble ia chloroform, and practically iasoluble ia ether and hexane. The method of preparation for diphenoxylate hydrochloride is available (11). Diphenoxylate hydrochloride [3810-80-8] (13) is an antidiarrheal that acts through an opiate receptor. It has effects both on propulsive motility and intestinal secretion. Commercial forms are mixed with atropiae to discourage abuse. [Pg.203]

Diphenoxylate Hydrochloride/Atropine Sulfate Brand name Lomotil Class Antidiarrheals... [Pg.22]

LS Jackson, et al. The evaluation and application of a radioimmunoassay for the measurement of diphenoxylic acid, the major metabolite of diphenoxylate hydrochloride (Lomotil), in human plasma. J Pharmacol Meth 18 189, 1987. [Pg.312]

DIPHENOXYLATE HYDROCHLORIDE WITH ATROPINE SULFATE (Lomotil)... [Pg.206]

Diphenoxylate is a meperidine congener that is approved for the treatment of diarrhea (see Chapter 37). Diphenoxylate hydrochloride is available only in combination with atropine sulfate (LOMOTIL, Others). The recommended daily dosage of diphenoxylate for the treatment of diarrhea in adults is 20 mg in divided doses. Difenoxin (motofen), a metabolite of diphenoxylate, has actions similar to those of the parent compound. [Pg.360]

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