Local SAR

Local SAR Rule and Descriptor-Based Models in Cardiac Channel Safety Pharmacology 560... 

To facilitate easy and quick generation of local QSARs, an in-house QSAR tool has been developed within Hoffman-La Roche. This tool allows all project teams to build a local model. Local SARs have been developed for several projects using hERG assay data and the in vitro screen for chromosomal damage in mammalian cells. These local SARs can also be applied in a more general sense. 

Surface Coll Mint Prevent High Local SAR Limit RF Current WKh Blocking Netvmiii Transmit Z If large Receive Z is small... 

If conductive loops (e.g., monitoring equipment or even coiled transmission line) are introduced into the scaimer, high local SAR levels may result (Fig. 24.6). Even straight conductors may increase local SAR significantly (Fig. 24.7). For patient safety, fiber optic devices should be used instead of conductors, when possible. 

Schenck, J. F., E. B. Boskamp, D. J. Schaefer, W. D. Barber, and R. H. Vander Heiden, 1998, Estimating Local SAR Produced by RF Transminer Q>ils Examples Using the Birdcage Coil. Abstracts of the International Society of Magnetic Resonance in Medicine, Sixth Meeting, Sydney, p. 649. 

The SAR index (SARI) provides a composite score of individual SAR continuity and discontinuity functions, which have been introduced by Peltason et al. [83,47]. However, in order to identify activity cliffs, local scoring functions focusing directly on SAR discontinuity in a local environment around a chemical structure of interest are more informative than global activity landscape overviews. Regions of SAR discontinuity provide a lot of information on the SAR of a particular chemical series for deriving a pharmacophore hypothesis. For this case, the compound discontinuity score was introduced [80]. This variation of the SARI formalism is aiming to quantify individual molecular contributions to local SAR discontinuity. Typically, the... 

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